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Varenicline
go.drugbank.com/drugs/DB01273ApprovedInvestigationalIn addition it acts on alpha3/beta4 and weakly on alpha3beta2 and alpha6-containing receptors. A full agonism was displayed on alpha7-receptors. On March 9, 2015, the U.S. … become aggressive or black out.
Categories: Drugs Used in Addictive Disorders, Drugs Used in Nicotine DependenceSafinamide
go.drugbank.com/drugs/DB06654ApprovedInvestigationalSafinamide is for the treatment of parkinson's disease. It was approved in Europe in February 2015, and in the United States on March 21, 2017.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: XADAGO 100 MG TABLETASRECUBIERTAS CON PELÍCULA, XADAGO 50 MG TABLETAS RECUBIERTAS CON PELÍCULAPolycarbophil
go.drugbank.com/drugs/DB09311ApprovedWithdrawnThis drug may also be used to help relieve the symptoms of irritable bowel syndrome or diarrhea. … The material possesses exceptionally high water-binding capacity. is not absorbed, does not interfere with the activity of digestive enzymes or intestinal absorption, possesses satisfactory stability,
Categories: Compounds used in a research, industrial, or household settingPholcodine
go.drugbank.com/drugs/DB09209ApprovedIllicit[A31738] Pholcodine activity is the suppression of unproductive cough and it also has a mild sedative effect with little or no analgesic effects. … It belongs to the opioid family of compounds and it is widely used.
Categories: Heterocyclic Compounds with 4 or More RingsEnalaprilat
go.drugbank.com/drugs/DB09477ApprovedInvestigationalAs angiotensin II is responsible for vasoconstriction and sodium reabsorption in the proximal tubule of the kidney, down-regulation of this protein results in reduced blood pressure and blood fluid volume … Enalaprilat is the active metabolite of the orally available pro-drug, [enalapril].
Categories: Agents Acting on the Renin-Angiotensin SystemEpcoritamab
go.drugbank.com/drugs/DB16672ApprovedInvestigationalEpcoritamab is an IgG1-bispecific antibody that simultaneously binds to CD3 on T-cells and CD20 on B-cells. … [L46516,L46556] In September 2023, epcoritamab was also approved in the EU for the same indication.
Lactitol
go.drugbank.com/drugs/DB12942Approved[A190912] Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in … Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose].
Categories: Compounds used in a research, industrial, or household settingVorinostat
go.drugbank.com/drugs/DB02546ApprovedInvestigationalpersists, gets worse, or comes back during or after treatment with other medicines. … Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease
Dihydrotachysterol
go.drugbank.com/drugs/DB01070ApprovedWithdrawnA vitamin D that can be regarded as a reduction product of vitamin D2.
Categories: Vitamin D and AnaloguesTisotumab vedotin
go.drugbank.com/drugs/DB16732ApprovedInvestigational[A238914] On September 20, 2021, the FDA granted accelerated approval to tisotumab vedotin for the treatment of recurrent or metastatic cervical cancer in adults in whom the disease progressed during … Each monoclonal antibody molecule carries an average of four MMAE molecules. Tisotumab vedotin is the first TF-directed ADC [A238914] that works by binding to TFs expressed on solid tumours.