Pholcodine

DB09209ApprovedIllicitSmall molecule

Pholcodine is an opioid antitussive used to suppress unproductive coughing. Pholcodine formula is 3-o-morpholinoethylmorphine and it is classified as an antitussive which is defined as an opioid cough suppressant.

Mechanism: The mechanism of action of pholcodine is directly performed in the medulla oblongata. In this site, it exerts analgesic properties on the peripheric reflexogenic receptors. This site is commonly known as the "cough center."
Curator reviewed · 1 reference
Primary indication: Pholcodine is indicated as a cough suppressant for the temporary relief of non-productive dry cough.Curator reviewed · 12 structured indications
Formula / weight: C₂₃H₃₀N₂O₄ · 398.4953 g/mol (avg)
Code names: IDS-NP-011(SECT.2)

Resolves to

Compound

UNIILPP64AWZ7LCAS509-67-1ChEMBLCHEMBL2105224ChEBI53579PubChem5311356KEGGD07385

Clinical / RWD

RxNorm33431ATCR05DA08

Structure

InChIKeyGPFAJKDEDBRFOS-FKQDBXSBSA-NSMILES[H][C@@]12OC3=C(OCCN4CCOCC4)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])C=C[C@@H]2O

Targets

P35372OPRM1P41145OPRK1P41143OPRD1

What you can answer from here — as of May 07, 2021

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

757Drug interactionsStructured to mechanism, not free text

1Clinical trialPhase, status and sponsor resolved per trial

12Structured indicationsCondition, population, route and combination as fields, not prose

2ContraindicationsEach with its own population and attribute set

25Marketed productsAcross 2 countries and 10 labellers

1ATC codeIncluding every combination product, plus 16 drug categories

10+ReferencesStructured and connected to the statements they support

Which drugs share a target with Pholcodine, and which of those have an active Phase 3 trial?

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