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Icosapent
go.drugbank.com/drugs/DB00159ApprovedInvestigationalNutraceuticalImportant polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. … A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane
Categories: Fatty Acids, Fatty Acids, Omega-3Synonyms: Timnodonic acid, Icosapentaenoic acidLeucovorin
go.drugbank.com/drugs/DB00650ApprovedInvestigational[A275451] It is primarily indicated for "leucovorin rescue" to diminish the hematologic and mucosal toxicity of high-dose methotrexate therapy in osteosarcoma and to treat inadvertent overdoses of folic … Leucovorin, also known as folinic acid or citrovorum factor, is a reduced form of folic acid that serves as a vital coenzyme in nucleic acid synthesis.
Categories: Folic Acid and Derivatives, Enzymes and CoenzymesSynonyms: Folinic acid, 10-Formyl-7,8-dihydrofolic acidVorinostat
go.drugbank.com/drugs/DB02546ApprovedInvestigationalVorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease
Categories: Antineoplastic and Immunomodulating Agents, Carboxylic AcidsSynonyms: Suberanilohydroxamic acid, Suberoylanilide hydroxamic acidDoconexent
go.drugbank.com/drugs/DB03756ApprovedInvestigationalIt is an omega-3 fatty acid and primary structural component of the human brain, cerebral cortex, skin, and retina thus plays an important role in their development and function. … A mixture of fish oil and primrose oil, doconexent is used as a high-docosahexaenoic acid (DHA) supplement. DHA is a 22 carbon chain with 6 cis double bonds with anti-inflammatory effects.
Mixtures: Iron Polysaccharides Folic Acid DHACategories: Fatty Acids, Fatty Acids, Omega-3Tolevamer
go.drugbank.com/drugs/DB01344ApprovedIt may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. … It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, HIV.
Categories: Drugs for Treatment of Hyperkalemia and Hyperphosphatemia, AcidsSynonyms: poly(styrene-4-sulfonic acid), Polystyrene sulfonic acidAtidarsagene autotemcel
go.drugbank.com/drugs/DB17538ApprovedInvestigationalAtidarsagene autotemcel, sold under the brand name Libmeldy, is a gene therapy comprising genetically modified autologous CD34+ enriched hematopoietic stem and progenitor cells transduced _ex vivo_ using … [L45191] Libmeldy was granted orphan designation by the EMA in April 2007, and was issued a marketing authorization in the EU in December 2020 for the treatment of certain manifestations of metachromatic
Categories: Alimentary Tract and Metabolism, Enzymes and CoenzymesSynonyms: Autologous CD34+ cells transduced with lentiviral vector which encodes for the aryl Sulfatase A complimentary deoxyribonucleic acid sequence, Autologous CD34+ cell enriched population that contains haematopoietic stem and progenitor cells (HSPC) transduced ex vivo using a lentiviral vector encoding the human arylsulfatase A (ARSA) geneDefibrotide
go.drugbank.com/drugs/DB04932ApprovedInvestigationalIt has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). … It is marketed under the brand names Dasovas (FM), Noravid, and Prociclide in a variety of countries. In the USA it is was approved in March, 2016 as Defitelio.
Categories: Nucleic Acids, Nucleotides, and Nucleosides, Blood and Blood Forming OrgansSynonyms: Defibrotide free acid, Defibrotide free acid (porcine)Fenoprofen
go.drugbank.com/drugs/DB00573ApprovedAn anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Synonyms: (+/-)-m-phenoxyhydratropic acid, 3-phenoxyhydratropic acidCategories: Antiinflammatory and Antirheumatic Products, Antiinflammatory and Antirheumatic Products, Non-SteroidsAutologous CD34+ hematopoietic stem and progenitor cells expressing adenosine deaminase
go.drugbank.com/drugs/DB18681ExperimentalAutologous CD34+ hematopoietic stem and progenitor cells expressing adenosine deaminase is an investigational lentiviral gene therapy. … It comprises autologous CD34+ hematopoietic stem and progenitor cells (HSPCs) that had been genetically modified ex vivo with EFS-ADA LV.
Synonyms: Autologous CD34+ hematopoietic stem and progenitor cells expressing adenosine deaminaseColistimethate
go.drugbank.com/drugs/DB01111ApprovedInvestigationalVet approvedColistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms.
Categories: Amino Acids, Peptides, and ProteinsSynonyms: Colistin methanesulfonic acid, Colistinmethanesulfonic acid