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Latanoprost
go.drugbank.com/drugs/DB00654ApprovedInvestigationalAnother benefit latanoprost is that it can be administered once a day.[A184490] … Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998.
Mixtures: Xalacom 50 Mikrogramm/ml + 5 mg/ml Augentropfen, LatanoTim-Vision 50 Mikrogramm/ml + 5 mg/ml AugentropfenCategories: Prostaglandins F, Synthetic, Compounds used in a research, industrial, or household settingItruvone
go.drugbank.com/drugs/DB21543InvestigationalItruvone is a small molecule drug. Itruvone is under investigation in clinical trial NCT02322086 (A Phase 2 Study of Cellular and Immunologic Changes in the Skin of Subjects Receiving PH-10). … Itruvone has a monoisotopic molecular weight of 296.21 Da.
Synonyms: Pregn-4-en-20-yn-3-oneFlubendazole
go.drugbank.com/drugs/DB08974ApprovedInvestigationalWithdrawnIt is available OTC in Europe.
Categories: Heterocyclic Compounds, 2-RingSynonyms: (5-(4-fluorobenzoyl)-1H-benzimidazole-2-yl)carbamic acid methyl ester, methyl 5-(p-fluorobenzoyl)-2-benzimidazolecarbamateThiamylal
go.drugbank.com/drugs/DB01154ApprovedVet approved(From Martindale, The Extra Pharmacopoeia, 30th ed, p919) … A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesSynonyms: dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione, 5-Allyl-5-(1-methylbutyl)-2-thiobarbituric acidEtomidate
go.drugbank.com/drugs/DB00292ApprovedInvestigationalIt has been proposed as an induction anesthetic.
Categories: Adrenergic alpha-2 Receptor Agonists, Heterocyclic Compounds, 1-RingSynonyms: R-(+)-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate, (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid ethyl esterBiperiden
go.drugbank.com/drugs/DB00810ApprovedInvestigationalWithdrawnA muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. … It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2D6 InhibitorsSynonyms: 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol, alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanolIrinotecan
go.drugbank.com/drugs/DB00762ApprovedInvestigationalIrinotecan is a topoisomerase inhibitor used for chemotherapy. It is a water-soluble analogue of [camptothecin], which is extracted from the Chinese tree _Camptotheca acuminate_. … [L50186] The active metabolite SN-38 is also a potent inhibitor of DNA topoisomerase I.
Categories: Topoisomerase 1 (TOP1) inhibitors, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 4-(2-(5-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)-1H-indol-1-yl, )ethyl)piperidine-1-carboxylateNitrazepam
go.drugbank.com/drugs/DB01595ApprovedA benzodiazepine derivative used as an anticonvulsant and hypnotic.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesSynonyms: 2,3-dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-one, 7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-oneGemfibrozil
go.drugbank.com/drugs/DB01241ApprovedInvestigational[L8525] Gemfibrozil was granted FDA approval on 21 December 1981.[L8525] … Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsSynonyms: 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansäure, 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acidPrimidone
go.drugbank.com/drugs/DB00794ApprovedVet approved[L11112] Primidone was developed by J Yule Bogue and H C Carrington in 1949.[A189522] Primidone was granted FDA Approval on 8 March 1954.[L11112]
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesSynonyms: 2-deoxyphenobarbital, 5-Phenyl-5-ethyl-Hexahydropyrimidine-4,6-dione