Identification
- Generic Name
- Flubendazole
- DrugBank Accession Number
- DB08974
- Background
Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.
- Type
- Small Molecule
- Groups
- Experimental, Withdrawn
- Structure
Structure for Flubendazole (DB08974)
- Weight
- Average: 313.2832
Monoisotopic: 313.08626947 - Chemical Formula
- C16H12FN3O3
- Synonyms
- (5-(4-fluorobenzoyl)-1H-benzimidazole-2-yl)carbamic acid methyl ester
- Flubendazol
- Flubendazole
- Flubendazolum
- methyl 5-(p-fluorobenzoyl)-2-benzimidazolecarbamate
- External IDs
- R 17,889
- R-17,889
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareMethotrexate The excretion of Methotrexate can be decreased when combined with Flubendazole. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- International/Other Brands
- Flubenol / Flumoxal
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Zelcom Tablet 500 mg/1 Oral OASIS TRADING 2018-11-15 Not applicable US 
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Zelcom Flubendazole (500 mg/1) Tablet Oral OASIS TRADING 2018-11-15 Not applicable US
Categories
- ATC Codes
- P02CA05 — Flubendazole
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as benzophenones. These are organic compounds containing a ketone attached to two phenyl groups.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Benzophenones
- Direct Parent
- Benzophenones
- Alternative Parents
- Aryl-phenylketones / Benzimidazoles / Benzoyl derivatives / Fluorobenzenes / Aryl fluorides / Imidazoles / Heteroaromatic compounds / Propargyl-type 1,3-dipolar organic compounds / Carboximidic acids and derivatives / Azacyclic compounds show 5 more
- Substituents
- Aromatic heteropolycyclic compound / Aryl fluoride / Aryl halide / Aryl ketone / Aryl-phenylketone / Azacycle / Azole / Benzimidazole / Benzophenone / Benzoyl show 18 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- organofluorine compound, carbamate ester, aromatic ketone, benzimidazoles (CHEBI:77095)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- R8M46911LR
- CAS number
- 31430-15-6
- InChI Key
- CPEUVMUXAHMANV-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22)
- IUPAC Name
- methyl N-[5-(4-fluorobenzoyl)-1H-1,3-benzodiazol-2-yl]carbamate
- SMILES
- COC(=O)NC1=NC2=C(N1)C=CC(=C2)C(=O)C1=CC=C(F)C=C1
References
- Synthesis Reference
U.S. Patent 3,657,267.
- General References
- Not Available
- External Links
- KEGG Drug
- D04200
- PubChem Compound
- 35802
- PubChem Substance
- 310264937
- ChemSpider
- 32932
- 25096
- ChEBI
- 77095
- ChEMBL
- CHEMBL1454946
- ZINC
- ZINC000003830847
- Wikipedia
- Flubendazole
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Suspension Oral 0.2 g Suspension Oral 2 g Tablet Oral 100 mg Tablet Oral 300 mg Tablet Oral 500 mg Suspension Oral 2000 mg Capsule, coated Oral 300 mg Tablet Oral 500 mg/1 - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) > 260 U.S. Patent 3,657,267. - Predicted Properties
Property Value Source Water Solubility 0.0288 mg/mL ALOGPS logP 2.87 ALOGPS logP 3.4 Chemaxon logS -4 ALOGPS pKa (Strongest Acidic) 9.17 Chemaxon pKa (Strongest Basic) 3.42 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 84.08 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 81.72 m3·mol-1 Chemaxon Polarizability 31.16 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Drug created at June 09, 2014 20:19 / Updated at February 21, 2021 18:52