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Gefapixant
go.drugbank.com/drugs/DB15097ApprovedIt has been estimated that 5-10% of adults globally suffer from chronic cough, which is defined as a cough lasting longer than eight weeks. … [L48596] Gefapixant is a novel antagonist of the P2X3 receptor that works to reduce the cough reflex in patients with chronic cough.
Categories: MATE 1 Substrates, MATE 2 SubstratesUrea C-14
go.drugbank.com/drugs/DB09513ApprovedInvestigationalUrea 14C is a urea molecule radiolabelled with a radioactive carbon-14. … To detect H. pylori, urea labeled with 14C is swallowed by the patient.
Synonyms: Urea 14 C, Urea C 14Products: HELITEST® CAPSULAS 37 KBQ UREA 14C, PYtest ®(Carbon-14-Urea 1.0 microCurie Breath Test)Edetate disodium anhydrous
go.drugbank.com/drugs/DB14600ApprovedInvestigationalVet approvedEdetate disodium anhydrous is a polyvalent chelating agent used to treat hypercalcemia and digitalis toxicity associated ventricular arrhythmias.[A204275]
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsVardenafil
go.drugbank.com/drugs/DB00862ApprovedVardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction. … Compared to [sildenafil] and [tadalafil], vardenafil is a more potent inhibitor of PDE5; however, its selectivity for other PDE isoforms is lower than the one detected for tadalafil.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: เลวิตรา(R) 5, Vardenafil 1 A Pharma 5 mg - FilmtablettenAbciximab
go.drugbank.com/drugs/DB00054ApprovedWithdrawnAbciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3.
Products: CLOTİNAB 10 MG/5 ML IV ENJEKSİYON İÇİN ÇÖZELTİ İÇEREN FLAKON, 1 ADET, ReoPro 2 mg/ml Injektionslösung oder InfusionslösungAcemetacin
go.drugbank.com/drugs/DB13783ApprovedInvestigationalAcemetacin is a carboxymethyl ester of indometacin. … It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin.
Categories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 2-RingProducts: RASLACOF-X, MERAVILL®Gestrinone
go.drugbank.com/drugs/DB11619ApprovedGestrinone, also known as ethylnorgestrienone, is a synthetic steroid of the 19-nortestosterone group that is marketed in Europe, Australia, and Latin America, though not the United States or Canada, and … is used primarily in the treatment of endometriosis.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesFerric maltol
go.drugbank.com/drugs/DB15598ApprovedInvestigationalFerric maltol is an iron(III) atom complexed with 3 maltol molecules to increase the bioavailability compared to iron(II), without depositing it in the duodenum as insoluble ferric hydroxide and phosphate … [A189288] Ferric maltol has been described in literature since at least the late 1980s as a potential treatment for iron deficiency.
Categories: Heterocyclic Compounds, 1-RingPegcetacoplan
go.drugbank.com/drugs/DB16694ApprovedInvestigationalPegcetacoplan is a complement inhibitor indicated in the treatment of paroxysmal nocturnal hemoglobinuria (PNH). … [A235000,A235005] Pegcetacoplan is a pegylated C3 inhibitor that can disrupt the processes leading to both forms of hemolysis that threaten patients with PNH.
Products: EMPAVELI® 54 MG/ML SOLUCIÓN INYECTABLESecnidazole
go.drugbank.com/drugs/DB12834ApprovedInvestigationalSecnidazole is a second-generation 5-nitroimidazole antimicrobial agent. … It is structurally related to other 5-nitroimidazoles, including [DB00916] and [DB00911], but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class
Mixtures: FUNEX® - S TABLETA, BATEN ® S TABLETAS RECUBIERTASCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring