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TRAF2 and NCK-interacting protein kinase
go.drugbank.com/bio_entities/BE0009399TargetHumansMAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed … Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
Polypeptides: TRAF2 and NCK-interacting protein kinaseVigabatrin
go.drugbank.com/drugs/DB01080ApprovedInvestigational[A202124] Its use is now generally reserved for patients who have failed alternative therapies, and its US approval by the FDA in 2009 mandated the creation of a drug registry to monitor patients for visual … [A202037] It was first introduced as an antiepileptic agent in the United Kingdom in 1989 and was used extensively until 1997, when an association with vision loss became apparent.
Products: SABRIL 500MG TABLETTrifarotene
go.drugbank.com/drugs/DB12808ApprovedInvestigationalto vitamin A and are analogous only in function. … Trifarotene is a topical retinoid cream used in the treatment of acne vulgaris that was first approved for use in the United States in October 2019.
Categories: Skin and Mucous Membrane Agents, Retinoids for Topical Use in AcneProducts: AKLIEF CREAM 50MCG/GEthosuximide
go.drugbank.com/drugs/DB00593ApprovedInvestigationalAn anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.
Products: Petinimid 250mg - KapselnUrapidil
go.drugbank.com/drugs/DB12661InvestigationalUrapidil has been investigated for the treatment of Hypertension During Pre-Eclampsia.
Products: EBRANTIL 25MG IV ENJEKSIYONLUK ÇÖZELTI IÇEREN AMPUL, AMPUL, 5 ADET, EBRANTIL 50MG IV ENJEKSIYONLUK ÇÖZELTI IÇEREN AMPUL, AMPUL, 5 ADETEstazolam
go.drugbank.com/drugs/DB01215ApprovedIllicitInvestigationalA benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam.
Categories: Hypnotics and Sedatives, Benzodiazepine hypnotics and sedativesProducts: Prosom Tab 2mgUlipristal
go.drugbank.com/drugs/DB08867ApprovedInvestigationalNevertheless, current and ongoing research into the agent's mechanism of action as an emergency contraceptive continue to provide potentially plausible evidence that ulipristal may, in fact, elicit activity … The exact mechanism of action for ulipristal is still currently debated, though there is evidence that it functions by inhibiting ovulation.
Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital SystemProducts: ESMYA TABLET 5MG, Esmya 5mg TabletsSodium acetate
go.drugbank.com/drugs/DB09395ApprovedInvestigationalIt can be used also in metabolic acidosis and for urine alkalinization. … Medically, sodium acetate is important component as an electrolyte replenisher when given intravenously. It is mainly indicated to correct sodium levels in hyponatremic patients.
Mixtures: Plasma-Lyte 148 and dextrose, Normosol-R and DextroseCategories: Blood and Blood Forming Organs, Blood Substitutes and Perfusion SolutionsPhentolamine
go.drugbank.com/drugs/DB00692ApprovedInvestigational[L48420, L48415, L48390] Phentolamine is administered intravenously, intramuscularly, submucosally, and topically. … anesthesia, and treatment of pharmacologically-induced mydriasis.
Synonyms: 2-(N-(m-hydroxyphenyl)-p-toluidinomethyl)imidazolineProducts: Rogitine 5mg/vialValganciclovir
go.drugbank.com/drugs/DB01610ApprovedInvestigationalValganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. … As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases.
Categories: Ganciclovir and prodrug, Nucleosides and NucleotidesProducts: VALCYTE 50MG/ML ORAL ÇÖZELTI IÇIN TOZ, VALCYTE TABLETS 450MG