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Glumetinib
go.drugbank.com/drugs/DB15630InvestigationalGlumetinib is under investigation in clinical trial NCT04270591 (Assess the Anti-tumor Activity and Safety of Glumetinib in Patient With Advanced C-met-positive Non-small Cell Lung Cancer).
Categories: Heterocyclic Compounds, 1-RingSynonyms: 6-(1-methyl-1h-pyrazol-4-yl)-1-((6-(1-methyl-1h-pyrazol-4-yl)imidazo(1,2-a)pyridin-3-yl)sulfonyl)-1h-pyrazolo(4,3-b)pyridineZalifrelimab
go.drugbank.com/drugs/DB15632InvestigationalZalifrelimab is under investigation in clinical trial NCT03894215 (Phase 2 Study of Anti-pd-1 Independently or in Combination With Anti-ctla-4 in Second-line Cervical Cancer).
Synonyms: A human monoclonal antibody targeting cytotoxic T lymphocyte associated protein 4 (ctla4), Immunoglobulin G1-kappa, anti-(homo sapiens CTLA4 (cytotoxic tlymphocyte-associated protein 4, cd152))Temelimab
go.drugbank.com/drugs/DB15634InvestigationalTemelimab is under investigation in clinical trial NCT02782858 (Clinical Trial Assessing the HERV-W Env Antagonist Gnbac1 for Efficacy in MS).
Categories: Recombinant Humanized IgG4 Monoclonal Antibody Against pHERV-W Envelope ProteinFluzoparib
go.drugbank.com/drugs/DB15637InvestigationalFluzoparib is under investigation in clinical trial NCT03863860 (A Trial of Maintenance Treatment With Fluzoparib Versus Placebo in Relapsed Ovarian Cancer Patients).
Categories: Heterocyclic Compounds, 1-RingN-(2-Aminoethyl)-1-aziridineethanamine
go.drugbank.com/drugs/DB15643ExperimentalFirst described in the literature in 2004, N-(2-Aminoethyl)-1-aziridineethanamine is an experimental angiotensin converting enzyme 2 inhibitor investigated for its use in treating cardiovascular disease
Synonyms: N-(2-((2-Aminoethyl)amino)ethyl)aziridine, N-(2-aminoethyl)-1 aziridine-ethanamineDihydromyricetin
go.drugbank.com/drugs/DB15645InvestigationalDihydromyricetin is under investigation in clinical trial NCT03606694 (Effect of Dihydromirycetin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes Mellitus).
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingAstraZeneca COVID-19 Vaccine
go.drugbank.com/drugs/DB15656ApprovedInvestigationalUpon review, the European Medicines Agency (EMA) determined that the vaccine was not associated with a higher overall risk of blood clots, but that it may be associated with very rare instances of blood … adenovirus capable of producing the spike (S) protein of SARS-CoV-2, allowing for the formation of endogenous antibodies against these proteins and, consequently, against SARS-CoV-2.
Categories: Complex MixturesSynonyms: ChAdOx-1-S[recombinant], ChAdOx1-S [recombinant]Ulotaront
go.drugbank.com/drugs/DB15665InvestigationalUnlike other drugs used for this condition, SEP-363856 does not bind to the dopamine D2 receptors, but exerts actions on the trace amine–associated receptor 1 (TAAR1) and 5-hydroxytryptamine type 1A (5 … SEP-363856 is a novel psychotropic drug being investigated for the treatment of schizophrenia.
Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 SubstratesGusacitinib
go.drugbank.com/drugs/DB15670InvestigationalGusacitinib is under investigation in clinical trial NCT02550678 (A Study of the Efficacy and Safety of ASN-002 in Adult Patients With Low-risk Nodular Basal Cell Carcinoma).
Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-(4-(4-(4-HYDROXY-PIPERIDIN-1-YL)-PHENYLAMINO)-5-OXO-5,6-DIHYDRO-PYRIMIDO(4,5-D)PYRIDAZIN-2-YL)-PIPERIDIN-4-YL-ACETONITRILENeisseria meningitidis group Y capsular polysaccharide tetanus toxoid conjugate antigen
go.drugbank.com/drugs/DB15682ApprovedInvestigationalSynonyms: Neisseria meningitidis group Y capsular polysaccharide tetanus toxoid conjugate antigen, Nimenrix component neisseria meningitidis group Y capsular polysaccharide tetanus toxoid conjugate antigen