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Cobimetinib
go.drugbank.com/drugs/DB05239ApprovedInvestigationalIt has been approved in Switzerland and the US, in combination with vemurafenib for the treatment of patients with unresectable or metastatic BRAF V600 mutation-positive melanoma. … Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction
Categories: MAP Kinase, antagonists & inhibitors, MAP Kinase Kinase 1, antagonists & inhibitorsDiazepam
go.drugbank.com/drugs/DB00829ApprovedIllicitInvestigationalVet approvedCombining diazepam, a proven effective therapy for acute repetitive seizures, with an auto-injector designed for subcutaneous administration that is quickly and easily administered offers the potential … This current development is subsequently an important addition to the rescue therapy tool chest for patients with epilepsy [L5200].
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesBenzydamine
go.drugbank.com/drugs/DB09084ApprovedInvestigationalIt is used topically for pain relief and anti-inflammatory treatment of the mouth, throat, or muscoskeletal system. … drug (NSAID), it has various physicochemical properties and pharmacologic activities that are different from those of traditional aspirin-like NSAIDs but facilitate benzydamine's mechanism of action as an
Categories: Topical Products for Joint and Muscular Pain, Antiinflammatory Products for Vaginal AdministrationProducts: TANTUM VERDE P, Biramine 3 mg/ml Spray zur Anwendung in der Mundhöhle, LösungAmisulpride
go.drugbank.com/drugs/DB06288ApprovedInvestigational[L32764] Amisulpride is also used as an antiemetic agent. … [A6752, L32764] Oral tablets of amisulpride is used in European countries as a treatment for acute and chronic schizophrenic disorders, as well as secondary negative symptoms in mental health disorders
Categories: P-glycoprotein substrates, Dopamine D2 Receptor AntagonistsOteseconazole
go.drugbank.com/drugs/DB13055ApprovedInvestigationalOteseconazole is an azole metalloenzyme inhibitor that targets fungal CYP51. … [L41635] Unlike previous-generation azole antifungals, oteseconazole has a high selectivity for CYP51 and little interaction with human cytochrome P450s.
Categories: Antimycotics for Systemic Use, Antiinfectives for Systemic UseDimethicone 410
go.drugbank.com/drugs/DB14005Approved[L1769] It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a concentration of 1-30%. … [L2162] The name dimethicone has a lot of nomenclature inconsistencies as it is used to refer to common names, generic names, trade names or even for the listing of mixtures.
Revefenacin
go.drugbank.com/drugs/DB11855ApprovedInvestigationalThe LAMA group falls into a parent category known as long-acting inhaled bronchodilators and this type of agents are recommended as a maintenance therapy for chronic obstructive pulmonary disease (COPD
Categories: Drugs for Obstructive Airway Diseases, Cytochrome P-450 SubstratesMethylchloroisothiazolinone
go.drugbank.com/drugs/DB14197ApprovedIt is found within many commercially available cosmetics, lotions, and makeup removers. … Sensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test.
Sodium sulfate
go.drugbank.com/drugs/DB09472ApprovedInvestigationalVet approvedSodium sulfate anhydrous is an electrolyte replenisher and is used in isosmotic solutions so that administration does not disturb normal electrolyte balance and does not lead to absorption or excretion
Mixtures: FORTRANS FOR ORAL SOLUTION, MOVIPREP Pulver zur Herstellung einer Lösung zum EinnehmenCategories: Drugs for ConstipationNadofaragene firadenovec
go.drugbank.com/drugs/DB17381ApprovedInvestigational[A255111] Nadofaragene firadenovec is formulated with an excipient (Syn-3) that facilitates gene transfer across the urothelium and promotes the transduction of IFNα2b. … Most patients with this condition undergo radical cystectomy since other non-surgical treatments are far less effective.