Sodium sulfate
Identification
- Name
- Sodium sulfate
- Accession Number
- DB09472
- Description
Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate anhydrous is an electrolyte replenisher and is used in isosmotic solutions so that administration does not disturb normal electrolyte balance and does not lead to absorption or excretion of water and ions.
- Type
- Small Molecule
- Groups
- Approved, Vet approved
- Structure
Structure for Sodium sulfate (DB09472)
- Weight
- Average: 142.042
Monoisotopic: 141.931268528 - Chemical Formula
- Na2O4S
- Synonyms
- Anhydrous sodium sulfate
- Sodium sulfate anhydrous
- Sodium sulfate, anhydrous
- Sodium sulphate anhydrous
- Sodium sulphate, anhydrous
- Sulfuric acid disodium salt, anhydrous
Pharmacology
- Indication
indicated for bowel cleansing prior to colonoscopy or barium enema X-ray examination.
- Associated Therapies
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
Induces catharsis by the osmotic effects of the unabsorbed sulfate salts and polyethylene glycol (PEG) in the GI tract. Specifically, sulfate salts provide sulfate anions, which are poorly absorbed, and PEG, which is primarily unabsorbed, causes water to be retained in the GI tract resulting in watery diarrhea.
- Mechanism of action
MoviPrep produces a watery stool leading to cleansing of the colon. The osmotic activity of polyethylene glycol 3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, and ascorbic acid, when taken with 1 liter of additional clear fluid, usually results in no net absorption or excretion of ions or water.
Target Actions Organism ACarbonic anhydrase 2 inhibitorHumans ACarbonic anhydrase 1 inhibitorHumans - Absorption
Absorption of sodium sulfate after ingestion in rats was investigated. 35)S-Radioactivity excreted in urine during 24 hr indicated almost complete absorption from GI tract. Determination in serum 2 hr after admin revealed 3-fold increase in sulfate concentration rapid and almost complete absorption of inorganic sulfate occurs after oral admin in rats.
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
Rectal effluent if unabsorbed sulfates ; urine (predominant route for absorbed sulfates )
- Half-life
Serum sulfate: 8.5 hours
- Clearance
- Not Available
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
Mouse LD50 (Oral): 5989mg/kg Mouse LDLo (Intravenous): 1220mg/kg Rabbit LD50 (Intravenous):1220mg/kg
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Unlock Additional DataAbacavir Abacavir may decrease the excretion rate of Sodium sulfate which could result in a higher serum level. Acarbose Acarbose may decrease the excretion rate of Sodium sulfate which could result in a higher serum level. Aceclofenac Aceclofenac may decrease the excretion rate of Sodium sulfate which could result in a higher serum level. Acemetacin Acemetacin may decrease the excretion rate of Sodium sulfate which could result in a higher serum level. Acetaminophen Acetaminophen may decrease the excretion rate of Sodium sulfate which could result in a higher serum level. Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium sulfate. Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Sodium sulfate which could result in a higher serum level. Aclidinium Aclidinium may decrease the excretion rate of Sodium sulfate which could result in a higher serum level. Acrivastine Sodium sulfate may decrease the excretion rate of Acrivastine which could result in a higher serum level. Acyclovir Acyclovir may decrease the excretion rate of Sodium sulfate which could result in a higher serum level. Additional Data Available- Extended DescriptionExtended DescriptionAvailable for Purchase
Extended description of the mechanism of action and particular properties of each drug interaction.
Learn more - SeveritySeverityAvailable for Purchase
A severity rating for each drug interaction, from minor to major.
Learn more - Evidence LevelEvidence LevelAvailable for Purchase
A rating for the strength of the evidence supporting each drug interaction.
Learn more - ActionActionAvailable for Purchase
An effect category for each drug interaction. Know how this interaction affects the subject drug.
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- Food Interactions
- No interactions found.
Products
- Product Ingredients
Ingredient UNII CAS InChI Key Sodium sulfate decahydrate 0YPR65R21J 7727-73-3 RSIJVJUOQBWMIM-UHFFFAOYSA-L - Active Moieties
Name Kind UNII CAS InChI Key Sodium cation ionic LYR4M0NH37 17341-25-2 FKNQFGJONOIPTF-UHFFFAOYSA-N Sulfate ion ionic 7IS9N8KPMG 14808-79-8 QAOWNCQODCNURD-UHFFFAOYSA-L - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Bi-peglyte Sodium sulfate (5.74 g) + Bisacodyl (5 mg) + Polyethylene glycol (59.55 g) + Potassium chloride (0.76 g) + Sodium bicarbonate (1.69 g) + Sodium chloride (1.46 g) Kit; Powder, for solution; Tablet, delayed release Oral Pendopharm Division Of Pharmascience Inc 2010-06-06 Not applicable Canada 
Clenz-Lyte Sodium sulfate (22.74 g/4L) + Polyethylene glycol (236 g/4L) + Potassium chloride (2.97 g/4L) + Sodium bicarbonate (6.74 g/4L) + Sodium chloride (5.86 g/4L) Powder, for solution Nasogastric; Oral Paddock Laboratories, Inc. 2010-06-07 2010-06-07 US 
ColPrep Kit Sodium sulfate decahydrate (17.5 g/22.7g) + Magnesium sulfate (1.6 g/22.7g) + Potassium sulfate (3.13 g/22.7g) Powder, for solution Oral KVK-Tech, Inc. 2016-12-27 2019-01-24 US Colyte Sodium sulfate (81.2 mg) + Polyethylene glycol (857.69 mg) + Potassium chloride (10.65 mg) + Sodium bicarbonate (24.02 mg) + Sodium chloride (20.87 mg) Powder, for solution Nasogastric; Oral Pendopharm Division Of Pharmascience Inc 1986-12-31 Not applicable Canada Colyte Sodium sulfate decahydrate (22.72 g/4L) + Polyethylene glycol (240 g/4L) + Potassium chloride (2.98 g/4L) + Sodium bicarbonate (6.72 g/4L) + Sodium chloride (5.84 g/4L) Powder, for solution Nasogastric MEDA Pharmaceuticals 2014-08-05 2021-09-30 US Colyte Sodium sulfate decahydrate (21.5 g/3.785L) + Polyethylene glycol (227.1 g/3.785L) + Potassium chloride (2.82 g/3.785L) + Sodium bicarbonate (6.36 g/3.785L) + Sodium chloride (5.53 g/3.785L) Powder, for solution Nasogastric; Oral Alaven Pharmaceutical 2010-09-01 2016-05-31 US Colyte with flavor packs Sodium sulfate decahydrate (22.72 g/4L) + Polyethylene glycol (240 g/4L) + Potassium chloride (2.98 g/4L) + Sodium bicarbonate (6.72 g/4L) + Sodium chloride (5.84 g/4L) Powder, for solution Nasogastric; Oral Alaven Pharmaceutical 1999-04-07 2016-08-31 US Eau Purgative Riga Sodium sulfate (1.056 g) + Magnesium sulfate (2.4 g) Liquid Oral Glendale Agencies 1978-12-31 1996-11-29 Canada Electropeg Solution Sodium sulfate (22.7 g) + Polyethylene glycol (238.8 g) + Potassium chloride (3 g) + Sodium bicarbonate (6.7 g) + Sodium chloride (5.8 g) Powder Oral Technilab Pharma Inc. 1998-04-20 1999-09-27 Canada GaviLyte - C TM Sodium sulfate (22.72 g/278.26g) + Polyethylene glycol (240 g/278.26g) + Potassium chloride (2.98 g/278.26g) + Sodium bicarbonate (6.72 g/278.26g) + Sodium chloride (5.84 g/278.26g) Powder, for solution Oral Lupin Pharmaceuticals 2009-01-06 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Sodium polysulthionate and folic acid Sodium sulfate decahydrate (8 mg/1) + Folic acid (1 mg/1) + Octasulfur (388 mg/1) + Sodium thiosulfate pentahydrate (1.8 mg/1) Capsule Oral Solubiomix 2016-08-24 2017-10-16 US Sodium polysulthionate, 5-methyltetrahydrofolate Sodium sulfate decahydrate (2 g/100g) + Levomefolic acid (.125 g/100g) + Octasulfur (97 g/100g) + Sodium thiosulfate pentahydrate (.45 g/100g) Powder Oral; Topical Solubiomix 2015-07-21 2016-01-12 US Sodium Polysulthionate, 5-mthf Sodium sulfate decahydrate (8 mg/1) + 5-methyltetrahydrofolic acid (.5 mg/1) + Octasulfur (388 mg/1) + Sodium thiosulfate pentahydrate (1.8 mg/1) Capsule Oral Solubiomix 2016-01-09 2016-01-12 US Xizflus Sodium sulfate decahydrate (2 g/100g) + 5-methyltetrahydrofolic acid (.125 g/100g) + Octasulfur (97 g/100g) + Sodium thiosulfate pentahydrate (.45 g/100g) Powder Oral; Topical Basiem 2015-07-14 2016-01-12 US Xizflus Sodium sulfate decahydrate (8 mg/1) + 5-methyltetrahydrofolic acid (.5 mg/1) + Octasulfur (388 mg/1) + Sodium thiosulfate pentahydrate (1.8 mg/1) Capsule Oral Basiem 2016-01-09 2016-01-12 US
Categories
- ATC Codes
- A06AD13 — Sodium sulfate
- A06AD — Osmotically acting laxatives
- A06A — DRUGS FOR CONSTIPATION
- A06 — DRUGS FOR CONSTIPATION
- A — ALIMENTARY TRACT AND METABOLISM
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as alkali metal sulfates. These are inorganic compounds in which the largest oxoanion is sulfate, and in which the heaviest atom not in an oxoanion is an alkali metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Alkali metal oxoanionic compounds
- Sub Class
- Alkali metal sulfates
- Direct Parent
- Alkali metal sulfates
- Alternative Parents
- Inorganic sodium salts / Inorganic oxides
- Substituents
- Alkali metal sulfate / Inorganic oxide / Inorganic salt / Inorganic sodium salt
- Molecular Framework
- Not Available
- External Descriptors
- inorganic sodium salt (CHEBI:32149)
Chemical Identifiers
- UNII
- 36KCS0R750
- CAS number
- 7757-82-6
- InChI Key
- PMZURENOXWZQFD-UHFFFAOYSA-L
- InChI
- InChI=1S/2Na.H2O4S/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2
- IUPAC Name
- disodium sulfate
- SMILES
- [Na+].[Na+].[O-]S([O-])(=O)=O
References
- General References
- Morris ME, Levy G: Serum concentration and renal excretion by normal adults of inorganic sulfate after acetaminophen, ascorbic acid, or sodium sulfate. Clin Pharmacol Ther. 1983 Apr;33(4):529-36. [PubMed:6831833]
- Cocchetto DM, Levy G: Absorption of orally administered sodium sulfate in humans. J Pharm Sci. 1981 Mar;70(3):331-3. [PubMed:7264905]
- Pubchem [Link]
- DRUGS.COM [Link]
- DAILYMED [Link]
- ChemIDplus [Link]
- inChem [Link]
- External Links
- KEGG Drug
- D01732
- KEGG Compound
- C13199
- PubChem Compound
- 24436
- PubChem Substance
- 347827857
- ChemSpider
- 22844
- BindingDB
- 50101993
- 1299926
- ChEBI
- 32149
- ChEMBL
- CHEMBL233406
- Wikipedia
- Sodium_sulfate
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Not Available Colonoscopy 1 4 Completed Basic Science Functional Constipation / Irritable Bowel Syndrome Characterized by Constipation 1 4 Completed Diagnostic Colon Adenomas / Colon Lesion / Colon Polyps 1 4 Completed Screening Colorectal Cancers 1 4 Completed Treatment Bowel Preparation for Colonoscopy 1 4 Completed Treatment Bowel preparation therapy / Colonoscopy / Endoscopy 1 4 Completed Treatment Colon Cleansing for Colonoscopy 1 4 Completed Treatment Colonoscopy 2 4 Completed Treatment Colorectal Cleansing Prior Operation 1 4 Completed Treatment Gastrointestinal Diseases 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Kit; powder, for solution; tablet, delayed release Oral Powder, for solution Oral 52.5 g Powder, for solution Nasogastric Powder, for solution Oral 45 g/750mL Liquid Oral Powder, for solution Oral 0.75 g/73.69g Powder, for solution Nasogastric; Oral Powder, for solution Oral 14.75 G Powder, for solution Oral 29.5 G Powder, for solution Oral 7.375 G Solution, concentrate Oral 17.51 g/176mL Solution Oral 3.276 g Powder, for solution Oral 1.685 g Powder Oral 5 g/100mL Kit Oral Solution Oral 100 g Powder, for solution Oral 4.7 g Powder, for solution Oral 7.5 g Powder, for solution Oral 118 g Tablet, effervescent Oral Powder, for solution Oral 59 g Powder, for solution Oral 100 g Powder, for solution Oral Powder, for solution Oral 14.58 G Powder, for solution Oral 58.32 G Powder, for solution Oral 14.57 g Powder, for solution Oral 58.3 g Solution Oral Powder Oral Solution, concentrate Oral Tablet Oral Granule, effervescent Oral 2.86 g Capsule Oral Powder Oral; Topical - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region Unlock Additional DataUS7169381 No 2007-01-30 2024-09-01 US US7658914 No 2010-02-09 2024-09-01 US US6946149 No 2005-09-20 2023-03-07 US US9326969 No 2016-05-03 2033-09-10 US US9592252 No 2017-03-14 2032-08-11 US US9707297 No 2017-07-18 2033-09-10 US US8999313 No 2015-04-07 2033-09-10 US US10016504 No 2018-07-10 2033-09-10 US US10646512 No 2012-03-25 2032-03-25 US US10792306 No 2012-03-09 2032-03-09 US US10780112 No 2012-03-09 2032-03-09 US Additional Data Available- Filed OnFiled OnAvailable for Purchase
The date on which a patent was filed with the relevant government.
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Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP -0.84 ChemAxon pKa (Strongest Acidic) -3 ChemAxon Physiological Charge -2 ChemAxon Hydrogen Acceptor Count 4 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 80.26 Å2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 11.53 m3·mol-1 ChemAxon Polarizability 5.81 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available
Targets
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Zinc ion binding
- Specific Function
- Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion in...
- Gene Name
- CA2
- Uniprot ID
- P00918
- Uniprot Name
- Carbonic anhydrase 2
- Molecular Weight
- 29245.895 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Zinc ion binding
- Specific Function
- Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.
- Gene Name
- CA1
- Uniprot ID
- P00915
- Uniprot Name
- Carbonic anhydrase 1
- Molecular Weight
- 28870.0 Da
References
Drug created on November 30, 2015 12:10 / Updated on January 09, 2021 11:41