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Berberine
go.drugbank.com/drugs/DB04115ApprovedInvestigationalWithdrawnIt is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.
Citicoline
go.drugbank.com/drugs/DB12153ApprovedInvestigationalWithdrawnIt has been investigated for the treatment, supportive care, and diagnosis of Mania, Stroke, Hypomania, Cocaine Abuse, and Bipolar Disorder, among others.
Monobenzone
go.drugbank.com/drugs/DB00600ApprovedWithdrawnMonobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. It exerts a depigmenting ef...
Phenformin
go.drugbank.com/drugs/DB00914ApprovedWithdrawnA biguanide hypoglycemic agent with actions and uses similar to those of metformin. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some c...
Dihydroergocornine
go.drugbank.com/drugs/DB11273ApprovedDihydroergocornine is one of the dihydrogenated ergot compounds that present very large hypotensive effects. It is an artificial derivative of the crude extract of ergot and later purified, ergocornine. The formation of dihydroergocornin...
VX-702
go.drugbank.com/drugs/DB05470InvestigationalIt acts as a p38 MAP kinase inhibitor. In the future, VX-702 may be investigated for combination with methotrexate, a commonly used therapy for RA.
Ginkgo biloba
go.drugbank.com/drugs/DB01381ApprovedInvestigationalNutraceuticalIt is originally native to China, and _ginkgo biloba_ extract has been used in traditional Chinese medicine for centuries.
Pravastatin
go.drugbank.com/drugs/DB00175ApprovedInvestigationalPravastatin is the 6-alpha-hydroxy acid form of mevastatin. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug....
Lisinopril
go.drugbank.com/drugs/DB00722ApprovedInvestigationalLisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction. Lisinopril and captopril are the only ACEIs that are not prodrugs. It functions by inhibition of angiot...
Metacycline
go.drugbank.com/drugs/DB00931ApprovedA broad-spectrum semisynthetic antibiotic related to tetracycline but excreted more slowly and maintaining effective blood levels for a more extended period.