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Baricitinib
go.drugbank.com/drugs/DB11817ApprovedInvestigationalBaricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthrit...
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesPritelivir
go.drugbank.com/drugs/DB11844InvestigationalPritelivir has been used in trials studying the prevention of HSV-2 and Genital Herpes.
Categories: P-glycoprotein substratesRevefenacin
go.drugbank.com/drugs/DB11855ApprovedInvestigationalRevefenacin is a novel biphenyl carbamate tertiary amine agent that belongs to the family of the long-acting muscarinic antagonists (LAMA). The labile primary amide in the structure produces a "soft-drug" site that allows rapid systemic ...
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesPenfluridol
go.drugbank.com/drugs/DB13791InvestigationalCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesTestosterone undecanoate
go.drugbank.com/drugs/DB13946ApprovedInvestigationalTestosterone undecanoate is the ester prodrug of testosterone and has a mid-chain fatty acid at the carbon 17β position. It was developed via fatty acid esterification of testosterone in order to achieve orally administer testosterone. T...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesStanolone acetate
go.drugbank.com/drugs/DB13951ExperimentalStanolone acetate is a synthetic androgen and anabolic steroid and a dihydrotestosterone ester that was never marketed.
Categories: P-glycoprotein substrates5-methoxy-N,N-dimethyltryptamine
go.drugbank.com/drugs/DB14010IllicitInvestigational5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a tryptamine with psychedelic properties. It is found in a wide variety of plant species, and a single psychoactive toad species, the Colorado River toad. This drug, as well as dimethyltryp...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesClinafloxacin
go.drugbank.com/drugs/DB14025ExperimentalClinafloxacin is a fluoroquinolone antibacterial currently under research. It has been proven to present good antibiotic properties. However, its approval and release have been halted due to the presence of serious side effects.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2C19 InhibitorsMadecassic acid
go.drugbank.com/drugs/DB14037InvestigationalCategories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 CYP2D6 InhibitorsValinomycin
go.drugbank.com/drugs/DB14057ExperimentalA cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately ...
Categories: P-glycoprotein inhibitors, P-glycoprotein substrates