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Mitapivat
go.drugbank.com/drugs/DB16236ApprovedInvestigational[A245478] On February 17, 2022, the FDA approved mitapivat as the first disease-modifying treatment for hemolytic anemia in adults with pyruvate kinase (PK) deficiency, a rare, inherited disorder leading
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesOxyquinoline
go.drugbank.com/drugs/DB11145ApprovedInvestigationalVet approvedOxyquinoline is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and pesticide properties. It is used as a stabilizer for hydrogen peroxide, where it is sometimes added in cosmetic products.
Mixtures: Fem pHSodium carbonate
go.drugbank.com/drugs/DB09460ApprovedWithdrawnSodium Carbonate is the disodium salt of carbonic acid with alkalinizing property. When dissolved in water, sodium carbonate forms carbonic acid and sodium hydroxide. As a strong base, sodium hydroxide neutralizes gastric acid thereby ac...
Nirmatrelvir
go.drugbank.com/drugs/DB16691ApprovedInvestigational[A234224,A234229,A234234] In 2020, Pfizer was investigating another potential treatment for SARS-CoV-2, [PF-07304814]. … Nirmatrelvir (PF-07321332) is an orally bioavailable 3C-like protease (3CL<sup>PRO</sup>) inhibitor that is the subject of clinical trial NCT04756531.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesAluminum zirconium octachlorohydrex gly
go.drugbank.com/drugs/DB11200ApprovedAluminum zirconium octachlorohydrex gly is complex that consists of aluminum zirconium octachlorohydrate and glycine. It is an active antiperspirant agent , . It diffuses into the sweat pores and prevents perspiration (sweat) from leavin...
Products: Secret Outlast pH Balanced Invisible, Lady Speed Stick Clinical Proof pH activeTramadol
go.drugbank.com/drugs/DB00193ApprovedInvestigationalTramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine. Due to its good tolerability profile and multimodal mechanism of actio...
Mixtures: DUODUET - PT, AUROMYOTRAM-P ® TABLETASCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesMomelotinib
go.drugbank.com/drugs/DB11763ApprovedInvestigationalMF includes primary MF (PMF), post-polycythemia vera (PV) MF, and post-essential thrombocythemia (ET) MF. Clinical manifestations of MF include anemia and thrombocytosis.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSildenafil
go.drugbank.com/drugs/DB00203ApprovedInvestigationalIn eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) . The result of doing so allows cGMP pre...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: Pb-sildenafil, SILEREthanol
go.drugbank.com/drugs/DB00898ApprovedInvestigationalA clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in ...
Mixtures: iBrea Micro Silver Hand with Pure Silver, iBrea Micro Silver Hand with Pure SilverCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersMifamurtide
go.drugbank.com/drugs/DB13615ApprovedInvestigationalAlso called L-MTP-PE, mifamurtide may be a liposomal form of of the active ingredient MTP-PE, which is a synthetic, less pyrogenic, and longer-acting derivative of muramyl dipeptide (MDP).