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Rilpivirine
go.drugbank.com/drugs/DB08864ApprovedInvestigational[A31328] It is a diarylpyrimidine derivative. … [A31329] The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potency and reduces the chance of resistance compared to other NNRTI's
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesAsparaginase Escherichia coli
go.drugbank.com/drugs/DB00023ApprovedInvestigationalIt is available as intramuscular or intravenous injections. … L-asparaginase of _E. coli_ is marketed under several different trade names, including Elspar, for the treatment of acute lymphoblastic leukemia (ALL) as part of a multi-agent chemotherapeutic regimen.
Etoposide
go.drugbank.com/drugs/DB00773ApprovedInvestigationalA semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexProducts: Etoposide - Liq IV 20mg/ml, SINTOPOZID 100 MG/5 ML IV KON. INFUZYON COZELTISI ICEREN FLAKON, 1 ADETNafamostat
go.drugbank.com/drugs/DB12598InvestigationalThe use of nafamostat in Asian countries is approved as an anticoagulant therapy for patients undergoing continuous renal replacement therapy due to acute kidney injury. … Nafamostat is a synthetic serine protease inhibitor that is commonly formulated with hydrochloric acid due to its basic properties.
Synonyms: p-Guanidinobenzoic acid ester with 6-hydroxy-2-naphthamidineOxymetazoline
go.drugbank.com/drugs/DB00935ApprovedInvestigational[L15062] As an effective decongestant, oxymetazoline is available in over-the-counter intranasal sprays used to relieve nasal and sinus congestion caused by a wide variety of conditions, such as common … Oxymetazoline is an imidazole derivative and a potent, direct-acting alpha (α)-adrenergic agonist with affinity to both α<sub>1</sub>- and α<sub>2</sub>-adrenoceptors.
Categories: Sympathomimetics Used as Decongestants, Cytochrome P-450 SubstratesProducts: OXY-NASE NASAL SPRAY 0.05% w/v, OXY-NASE PAEDIATRIC NASAL SPRAY 0.025% w/vHalcinonide
go.drugbank.com/drugs/DB06786ApprovedWithdrawnHalcinonide is a corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, and is distributed as a cream and ointment.
Categories: Corticosteroids, Very Potent (Group IV), Cytochrome P-450 SubstratesParomomycin
go.drugbank.com/drugs/DB01421ApprovedInvestigationalAn oligosaccharide antibiotic produced by various streptomyces. [PubChem]
Synonyms: Monomycin A, Zygomycin A1Maralixibat
go.drugbank.com/drugs/DB16226ApprovedInvestigationalMaralixibat (also known as SHP625, LUM001, and lopixibat) is an ileal bile acid transporter inhibitor, like [odevixibat]. … [A239249] Surgical interventions such as partial external bile diversion and ileal exclusion have also been used as treatments.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsFelypressin
go.drugbank.com/drugs/DB00093InvestigationalA synthetic nonapeptide comprising cysteinyl, phenylalanyl, phenylalanyl, glutaminyl, asparaginyl, cysteinyl, prolyl, lysyl, and glycinamide residues in sequence, with a disulfide bridge joining the two … It is a non-catecholamine vasoconstrictor used in local anaesthetic injections for dental use, and is an ingredient of preparations that have been used for treatment of pain and inflammation of the mouth
Polymyxin B
go.drugbank.com/drugs/DB00781ApprovedInvestigationalVet approvedPolymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line[A176429].
Mixtures: OTEK-P EAR DROPS, AK-Trol