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Displaying results 1811 - 1820 of 5089 in total
  1. Target

    Vasoactive intestinal polypeptide receptor 1

    go.drugbank.com/bio_entities/BE0013137
    TargetHumans

    Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38 (PubMed:35477937, PubMed:8179610). … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors.

    Synonyms: VIP-R-1
  2. Drug

    Vatreptacog alfa

    go.drugbank.com/drugs/DB12409
    Investigational

    Vatreptacog Alfa (Activated) has been used in trials studying the treatment of Haemophilia B, Haemophilia A, Congenital Bleeding Disorder, Haemophilia A With Inhibitors, and Haemophilia B With Inhibitors.

    Categories: Factor VII
  3. Drug

    Marzeptacog alfa (activated)

    go.drugbank.com/drugs/DB15278
    Investigational

    Marzeptacog alfa (activated) is under investigation in clinical trial NCT01439971 (Phase 1 Safety, Pharmacokinetics And Pharmacodynamics Study Of Recombinant Factor VIIa Variant (813d) In Adult Subjects With Hemophilia).

    Categories: Factor VII
  4. Drug

    Clioquinol

    go.drugbank.com/drugs/DB04815
    ApprovedVet approvedWithdrawn

    Clioquinol was withdrawn in 1983 due to neurotoxicity.

    Mixtures: CORTINOL D
  5. Drug

    Segesterone acetate

    go.drugbank.com/drugs/DB14583
    Approved

    Due to its rapid hepatic metabolism, segesterone acetate must be administered parenterally [A37090].

  6. Drug

    Ganaxolone

    go.drugbank.com/drugs/DB05087
    ApprovedInvestigational

    Ganaxolone is the 3β-methylated synthetic analog of allopregnanolone, a metabolite of progesterone. Ganaxolone belongs to a class of compounds referred to as neurosteroids. Endogenous neurosteroids, which comprise certain metabolites of ...

  7. Drug

    Tradipitant

    go.drugbank.com/drugs/DB12580
    ApprovedInvestigational

    Tradipitant is a selective, high-affinity antagonist at human substance P/neurokinin-1 (NK-1) receptors. NK-1 receptors are expressed in the brainstem and nucleus tractus solitarius, which receives emetogenic signals from various stimuli...

  8. Drug

    LI-301

    go.drugbank.com/drugs/DB05509
    Experimental

    It has a novel mode of action combining both the light effect of a Selective Serotonin Reuptake Inhibitor ("SSRI")(most likely antagonistic at 5HT1a receptors) and antagonism at mu-opioid receptors.

  9. Drug

    Aluminum sulfate

    go.drugbank.com/drugs/DB11239
    Approved

    Aluminum (Al), also spelled aluminum, chemical element, a lightweight, silvery-white metal of main Group 13 (IIIa, or boron group) of the periodic table . It is a chemical agent used in water purification, the pH regulation of garden soi...

    Mixtures: ACETATO DE ALUMINIO, ACETATO DE ALUMINIO POLVOProducts: Sil Trax As No 8, Sil Trax As No 10
  10. Drug

    Melatonin

    go.drugbank.com/drugs/DB01065
    ApprovedInvestigationalNutraceuticalVet approved

    Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the ...

    Products: Essential Oil