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Displaying results 1851 - 1860 of 10000 in total
  1. Target

    Serine/threonine-protein kinase TAO2

    go.drugbank.com/bio_entities/BE0004632
    TargetHumans

    Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. … Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway.

    Synonyms: Kinase from chicken homolog C, Thousand and one amino acid protein kinase 2
  2. Drug

    N-[2-(1-Formyl-2-Methyl-Propyl)-1-(4-Piperidin-1-Yl-but-2-Enoyl)-Pyrrolidin-3-Yl]-Methanesulfonamide

    go.drugbank.com/drugs/DB03890
    Experimental

    Synonyms: N-[2-(1-Formyl-2-Methyl-Propyl)-1-(4-Piperidin-1-Yl-but-2-Enoyl)-Pyrrolidin-3-Yl]-Methanesulfonamide
  3. Drug

    4-(2-Amino-Ethoxy)-2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Amino]-but-3-Enoic Acid

    go.drugbank.com/drugs/DB03287
    Experimental

    Synonyms: 4-(2-Amino-Ethoxy)-2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Amino]-but-3-Enoic Acid
  4. Indication

    Erythropoietin Resistant Anemia (EPO Resistant Anemia)

    go.drugbank.com/conditions/DBCOND0161719
    Drugs: Vadadustat
    Synonyms: Anemia co-occurrent and due to chronic kidney disease, Anaemia co-occurrent and due to chronic kidney disease
  5. Drug

    Guanoxan

    go.drugbank.com/drugs/DB13211
    Approved

    Guanoxan was approved in the UK but was withdrawn from the market due to hepatotoxicity. … Guanoxan is an antihypertensive agent similar in its mechanism of action to guanethidine; may cause liver damage.

  6. Drug

    Eucalyptus oil

    go.drugbank.com/drugs/DB11114
    Approved

    Eucalyptus oil is a distilled oil derived from the leaves of the tree Eucalyptus. … Eucalyptus oil can be applied directly to the skin for pain and swelling of respiratory tract mucous membranes, joint pain, genital herpes, and nasal stuffiness.

    Mixtures: Zam-Buk Ointment, NORAVER UCategories: Other Cold and Cough Preparations
  7. Indication

    Relapsed or Refractory Follicular Lymphoma

    go.drugbank.com/conditions/DBCOND0071783
    Drugs: Mosunetuzumab
    Synonyms: Relapsed and Refractory Follicular Lymphoma
  8. Drug

    Remestemcel-L

    go.drugbank.com/drugs/DB13973
    ApprovedInvestigationalWithdrawn

    The mesenchymal stem cells are derived from the bone marrow of unrelated and human leukocyte antigen (HLA)–unmatched healthy adult donors and have the ability to differentiate into different tissue cells … [L52008] aGvHD is a T-cell mediated disease that occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues [A31822] developed by 30-80%

  9. Target

    Interleukin-33

    go.drugbank.com/bio_entities/BE0010097
    TargetHumans

    Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016, PubMed:19841166). … Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).

    Synonyms: Nuclear factor from high endothelial venules
  10. Drug

    Zinc acetate

    go.drugbank.com/drugs/DB14487
    ApprovedInvestigational

    Mixtures: Up and Up itch relief, Benadryl Bug Bite ReliefCategories: Alimentary Tract and Metabolism, Various Alimentary Tract and Metabolism Products