Search
Mephentermine
go.drugbank.com/drugs/DB01365ApprovedWithdrawnAlthough the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. … A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeCholestyramine
go.drugbank.com/drugs/DB01432ApprovedInvestigationalCholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins.
Categories: Compounds used in a research, industrial, or household settingProducts: COLESTIRAMINA 4 G., COLESTYRAMIN HEXAL 4GCobimetinib
go.drugbank.com/drugs/DB05239ApprovedInvestigationalIt has been approved in Switzerland and the US, in combination with vemurafenib for the treatment of patients with unresectable or metastatic BRAF V600 mutation-positive melanoma. … Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction
Products: COTELLIC FILM-COATED TABLET 20 MG, COTELLIC® (COBIMETINIB) 20 MG TABLETAS RECUBIERTASOlaparib
go.drugbank.com/drugs/DB09074ApprovedInvestigational[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell … Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.
Products: LYNPARZA® 100 MG, LYNPARZA® 150 MGEstrone
go.drugbank.com/drugs/DB00655ApprovedEstrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. … It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione.
Categories: Sex Hormones and Modulators of the Genital SystemImelasomeran
go.drugbank.com/drugs/DB17090ApprovedInvestigational[L45320] It encodes for the viral spike protein of the Omicron BA.1 variant of SARS-CoV-2, a particularly infectious variant of concern first documented in 2021.[L43922] … Imelasomeran was first approved in Canada on September 1, 2022, as one-half of Moderna's Spikevax Bivalent COVID-19 mRNA vaccine.
Repotrectinib
go.drugbank.com/drugs/DB16826ApprovedInvestigational[A262056] ROS1 mutations are one of the defined oncogenic drives of NSCLC, and the solvent-front mutation ROS1 G2032R is responsible for 50 to 60% of [crizotinib]-resistant cases. … [A262066] On November 15th, 2023, the FDA approved repotrectinib under the brand name Augtyro for the treatment of locally advanced or metastatic ROS1-Positive NSCLC.
Levoketoconazole
go.drugbank.com/drugs/DB05667Approved[A244083] Levoketoconazole is one of two enantiomers present in racemic [ketoconazole]. … [A244078, A244083] [Ketoconazole] has been used both on- and off-label to treat CS due to its ability to inhibit cortisol production.
Dihydroergocristine
go.drugbank.com/drugs/DB13345ApprovedDihydroergocristine is part of the ergoloid mixture products.[L2637] It is a semisynthetic ergot alkaloid and thus, it is characterized by a structural skeleton formed by an alkaloid ergoline.
Categories: Heterocyclic Compounds with 4 or More RingsFormic acid
go.drugbank.com/drugs/DB01942ApprovedInvestigationalIt is an important intermediate in chemical synthesis and occurs naturally, most famously in the venom of bee and ant stings.
Mixtures: Nutri-Tab OB, Nutri-Tab OB plus DHA