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Levofloxacin
go.drugbank.com/drugs/DB01137ApprovedInvestigationalLevofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. … [L11638] Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones
Mixtures: TRILEVO 500 MG+30 MG+ 1000 MG TEDAVİ PAKETİ, Ducressa (Dexamethasone 1mg/ml + Levofloxacin 5mg/ml) eye drops, solutionCategories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2C9 InhibitorsSugammadex
go.drugbank.com/drugs/DB06206ApprovedInvestigationalSugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015. … Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery.
Categories: Compounds used in a research, industrial, or household settingProducts: Sugagelan 100 mg/ml-Injektionslösung, Areversin 100 mg/ml InjektionslösungCiprofloxacin
go.drugbank.com/drugs/DB00537ApprovedInvestigationalCiprofloxacin is a second generation fluoroquinolone that has spawned many derivative antibiotics. … [A178870] It is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of bacterial infections.
Mixtures: ORCIPOL 500 MG/500 MG FILM TABLET, 10 ADET, ORNISASIN 500 MG/500 MG FILM TABLET, 10 ADETCategories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP3A InhibitorsAstemizole
go.drugbank.com/drugs/DB00637ApprovedWithdrawnAstemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms.
Categories: Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: ALMIZOL 10 MG TABLET, 10 ADET, ULKAMIZOL 10 MG TABLET, 10 ADETEsmolol
go.drugbank.com/drugs/DB00187ApprovedInvestigationalWithdrawnThe FDA withdrew its approval for the use of all parenteral dosage form drug products containing esmolol hydrochloride that supply 250 milligrams/milliliter of concentrated esmolol per 10-milliliter ampule … Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesProducts: Brevibloc 100 mg/10 ml - Infusionslösung, Esmolol Amomed 100 mg/10 ml InfusionslösungMycophenolic acid
go.drugbank.com/drugs/DB01024ApprovedInvestigationalMycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. … Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis.
Categories: Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: CELLCEPT 500 MG FİLM KAPLI TABLET, 150 ADET, MYFORTIC (180 MG )Sibutramine
go.drugbank.com/drugs/DB01105ApprovedIllicitWithdrawnIt is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled substance in the United States. … In October 2010, Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: SINHABIT 15 MG, SIBUTRAMINA MK 15 MG CAPSULASColistin
go.drugbank.com/drugs/DB00803ApprovedInvestigationalIt is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes.
Categories: Drugs that are Mainly Renally Excreted with a Narrow Therapeutic IndexProducts: APSASOL COLISTIN Powder 100 mg/g, Colit 150 MIU Water Soluble PowderEphedrine
go.drugbank.com/drugs/DB01364ApprovedInvestigational[A193698] Ephedrine acts as both a direct and indirect sympathomimetic. … [A193701,A193704,L12975] Ephedrine was granted a type 7 FDA Approval on 29 April 2016.[L12975]
Mixtures: BROKSIN 6.66 MG/5 ML+100 MG/5 ML SURUP, 150 ML, OPSIS SURUP, 150 MLSynonyms: L-Ephedrine, L(−)-ephedrineVerapamil
go.drugbank.com/drugs/DB00661ApprovedInvestigationalgreater potency than the R-enantiomer, but is metabolized at a higher rate. … Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina,[L8791] and was the first calcium channel antagonist to be introduced
Mixtures: VERAPIN 180 MG/2 MG FILM KAPLI TABLET, 28 ADET, VERACOMB MR 180/2 MG KAPSÜL, 28 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates