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Displaying results 181 - 190 of 157280 in total
  1. Drug

    Copanlisib

    go.drugbank.com/drugs/DB12483
    ApprovedInvestigational

    PI3K, a lipid kinase that activates downstream signalling pathways involved in cell survival and growth, that exists in different isoforms and is often overexpressed in hematological malignancies. … Copanlisib is a selective pan-Class I phosphoinositide 3-kinase (PI3K) inhibitor with preferential activity against the alpha and delta isoforms.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: 2-AMINO-N-(7-METHOXY-8-(3-(MORPHOLIN-4-YL)PROPOXY)-2,3-DIHYDROIMIDAZO(1,2-C)QUINAZOLIN-5-YL(PYRIMIDINE-5-CARBOXAMIDE, 2-AMINO-N-(7-METHOXY-8-(3-MORPHOLIN-4-YLPROPOXY)-2,3-DIHYDROIMIDAZO(1,2-C)QUINAZOLIN-5-YL)PYRIMIDINE-5-CARBOXAMIDE
  2. Drug

    Cannabidiolic acid methyl ester

    go.drugbank.com/drugs/DB17825
    Experimental

    Synonyms: 2-{2,4-dihydroxy-3-[(1R,6R)-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-6-pentylphenyl}acetic acid, CBDA-ME
  3. Drug

    Etomidate

    go.drugbank.com/drugs/DB00292
    ApprovedInvestigational

    Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.

    Categories: Adrenergic alpha-2 Receptor Agonists, Heterocyclic Compounds, 1-RingSynonyms: (+)-ethyl 1-(α-methylbenzyl)imidazole-5-carboxylate, R-(+)-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate
  4. Drug

    Leriglitazone

    go.drugbank.com/drugs/DB15021
    ApprovedInvestigational

    brain lesions and a Neurological Functional Score of 0 or 1. … [L147264] The European Commission granted marketing authorization for leriglitazone under exceptional circumstances on September 21, 2026, for cALD in male patients aged 2 to 12 years with non-gadolinium-enhancing

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: 2,4-thiazolidinedione, 5-((4-(2-(5-(1-hydroxyethyl)-2-pyridinyl)ethoxy)phenyl)methyl)-, All-ambo-5-((4-(2-(5-(1-hydroxyethyl)pyridin-2-yl)ethoxy)phenyl)methyl)-1,3-thiazole-2,4(3H,5H)-dione
  5. Drug

    Ergotamine

    go.drugbank.com/drugs/DB00696
    Approved

    A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders.

    Mixtures: CAFERGOT 1 MG/100 MG TABLET, 30 ADET, ERGOTAMINA 1 MG + CAFEINA 100 MG TABLETASCategories: Serotonin 5-HT1 Receptor Agonists, Serotonin 5-HT2 Receptor Agonists
  6. Drug

    Levomenthol

    go.drugbank.com/drugs/DB00825
    ApprovedInvestigational

    Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. … Forming clear or white waxy, crystalline substance, menthol is typically solid at room temperature. (-)-Menthol is the naturally-occurring and main form of menthol, and is assigned the (1R,2S,5R) configuration

    Mixtures: KAMFOLIN 150 MG/G+100 MG/G MERHEM, 50 G, VİCKS İNHALER 415,4 MG + 415,4 MG/1 G BURUN ÇUBUĞUCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  7. Drug

    Benoxaprofen

    go.drugbank.com/drugs/DB04812
    ApprovedWithdrawn

    The holder of the approved application voluntarily withdrew Oraflex tablets from the market on August 5, 1982.

    Synonyms: (1)-2-(4-Chlorophenyl)benzoxazole-5-propionic acid, 2-(4-chlorophenyl)-α-methyl-5-benzoxazoleacetic acid
  8. Drug

    Palbociclib

    go.drugbank.com/drugs/DB09073
    ApprovedInvestigational

    Palbociclib is a piperazine pyridopyrimidine[A176792] that acts in the cell cycle machinery. … It is a second generation cyclin-dependent kinase inhibitor[A176798] selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties.

    Mixtures: REAMPLA®, REAMPLA®Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
  9. Drug

    (1Z)-2-HYDROXY-3-OXOHEX-1-EN-1-YL DIHYDROGEN PHOSPHATE

    go.drugbank.com/drugs/DB06881
    Experimental

    Synonyms: (1Z)-2-HYDROXY-3-OXOHEX-1-EN-1-YL DIHYDROGEN PHOSPHATE
  10. Drug

    5-fluoro-2'-deoxyuridine-5'-monophosphate

    go.drugbank.com/drugs/DB03761
    Experimental

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 5-fluoro-2'-deoxyuridine-5'-monophosphate, 5-fluorodeoxyuridine monophosphate