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Leflunomide
go.drugbank.com/drugs/DB01097ApprovedInvestigationalLeflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous.
Products: AS-LUNEX 10 MG TABLET, 30 ADET, AS-LUNEX 20 MG TABLET, 30 ADETGaretosmab
go.drugbank.com/drugs/DB16379ApprovedInvestigational[L63940,L64047] It is the second therapy approved for FOP, following [palovarotene] (Sohonos), which was approved in 2023, and is the first FOP therapy shown to reduce clinician-assessed flare-ups. … [L63940] It is administered by intravenous infusion every four weeks.
Tofacitinib
go.drugbank.com/drugs/DB08895ApprovedInvestigationalKnown adverse effects include nausea and headache as well as more serious immunologic and hematological adverse effects. Tofacitinib is marketed under the brand name Xeljanz by Pfizer. … Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function.
Mesenchymal stem cell-derived exosomes
go.drugbank.com/drugs/DB24445InvestigationalMesenchymal Stem Cell-Derived Exosomes is a biologic drug. … Mesenchymal Stem Cell-Derived Exosomes is under investigation in clinical trial NCT07183384 (MSC Exosome Therapy for Post-Preeclampsia Endothelial Dysfunction).
Synonyms: Mesenchymal Stem Cell-Derived Exosomes, exosomes derived from mesenchymal stem cellsHaemophilus influenzae type B strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen
go.drugbank.com/drugs/DB10076Approvedcontains the *Haemophilus influenzae* type b capsular polysaccharide (polyribosyl-ribitol-phosphate, PRP), a high-molecular-weight polymer prepared from the *H. influenzae* type b strain 1482 grown in a semi-synthetic … The toxoid antigen is purified and toxin-inactivated.
Candicidin
go.drugbank.com/drugs/DB01152ApprovedInvestigationalWithdrawnCandicidin is administered intravaginally in the treatment of vulvovaginal candidiasis. … Candicidin is an antibiotic obtained from a streptomyces (Streptomyces griseus) and active against some fungi of the genus Candida (C. albicans).
Categories: Genito Urinary System and Sex HormonesCalcium
go.drugbank.com/drugs/DB01373ApprovedInvestigationalNutraceuticalCirculating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. … Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis.
Mixtures: Fem Time Tab, Kordel"s Bio-Liquid Women"s Multi With Fish Oil VegicapProducts: Tall G U, AAR OS NPicosulfuric acid
go.drugbank.com/drugs/DB09268ApprovedInvestigationalPicosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery.
Raxibacumab
go.drugbank.com/drugs/DB08902ApprovedInvestigationalRaxibacumab is produced by recombinant DNA technology in a murine cell expression system. FDA approved on December 14, 2012. … Raxibacumab is a human IgG1λ monoclonal antibody that binds the protective antigen (PA) component of B. anthracis toxin. Raxibacumab has a molecular weight of approximately 146 kilodaltons.
Categories: Antiinfectives for Systemic UseRimonabant
go.drugbank.com/drugs/DB06155ApprovedWithdrawnIt was rejected for approval for use in the United States. … Rimonabant is the first selective CB1 receptor blocker to be approved for use anywhere in the world. Rimonabant is approved in 38 countries including the E.U., Mexico, and Brazil.