Haemophilus influenzae type B strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names

Acthib, Pentacel

Generic Name

Haemophilus influenzae type B strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen

DrugBank Accession Number

DB10076

Background

Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen is a vaccine for intramuscular injection used in the prevention of invasive disease caused by Haemophilus influenzae type b. H. influenzae is a Gram-negative coccobacillus that can cause infections including sepsis and meningitis. The vaccine contains the Haemophilus influenzae type b capsular polysaccharide (polyribosyl-ribitol-phosphate, PRP), a high-molecular-weight polymer prepared from the H. influenzae type b strain 1482 grown in a semi-synthetic medium, covalently bound to tetanus toxoid ¹. The toxoid antigen is purified and toxin-inactivated.

Type

Biotech

Groups

Approved, Investigational

Biologic Classification

Vaccines
Inactivated / Toxoid / Conjugate

Synonyms

Haemophilus influenzae type B strain 1482, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine

Pharmacology

Indication

Not Available

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Associated Conditions

Invasive Infection caused by Haemophilus Influenzae Type B

Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions: This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions: Not Available

Products

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Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
ActHIB	Injection, powder, lyophilized, for solution; Kit	10 ug/0.5mL	Intramuscular	Sanofi Pasteur Inc.	1993-03-30	Not applicable

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Act-hib	Haemophilus influenzae type B strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen (10 mcg)	Kit; Powder, for solution	Intramuscular	Sanofi Pasteur Limited	1992-12-31	Not applicable
Infanrix-hexa	Haemophilus influenzae type B strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen (10 mcg / 0.5 mL) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (25 mcg / 0.5 mL) + Bordetella pertussis pertactin antigen (8 mcg / 0.5 mL) + Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) (25 mcg / 0.5 mL) + Clostridium tetani toxoid antigen (formaldehyde inactivated) (40 mcg / 0.5 mL) + Clostridium tetani toxoid antigen (formaldehyde inactivated) (10 lf / 0.5 mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (25 lf / 0.5 mL) + Hepatitis B Vaccine (Recombinant) (10 mcg / 0.5 mL) + Poliovirus type 1 antigen (formaldehyde inactivated) (40 unit / 0.5 mL) + Poliovirus type 2 antigen (formaldehyde inactivated) (8 unit / 0.5 mL) + Poliovirus type 3 antigen (formaldehyde inactivated) (32 unit / 0.5 mL)	Suspension	Intramuscular	Glaxosmithkline Inc	2008-12-04	Not applicable
Menhibrix	Haemophilus influenzae type B strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen (2.5 ug/0.5mL) + Meningococcal polysaccharide vaccine group C (5 ug/0.5mL) + Meningococcal polysaccharide vaccine group Y (5 ug/0.5mL)	Injection, powder, lyophilized, for solution	Intramuscular	GlaxoSmithKline Biologicals SA	2013-09-03	2013-11-27
Menhibrix	Haemophilus influenzae type B strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen (2.5 ug/0.5mL) + Meningococcal polysaccharide vaccine group C (5 ug/0.5mL) + Meningococcal polysaccharide vaccine group Y (5 ug/0.5mL)	Kit	Intramuscular	GlaxoSmithKline Biologicals SA	2013-09-03	2017-09-17
Pediacel	Haemophilus influenzae type B strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen (10 mcg / 0.5 mL) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (20 mcg / 0.5 mL) + Bordetella pertussis fimbriae 2/3 antigen (5 mcg / 0.5 mL) + Bordetella pertussis pertactin antigen (3 mcg / 0.5 mL) + Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) (20 mcg / 0.5 mL) + Clostridium tetani toxoid antigen (formaldehyde inactivated) (5 lf / 0.5 mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (15 lf / 0.5 mL) + Poliovirus type 1 antigen (formaldehyde inactivated) (40 unit / 0.5 mL) + Poliovirus type 2 antigen (formaldehyde inactivated) (8 unit / 0.5 mL) + Poliovirus type 3 antigen (formaldehyde inactivated) (32 unit / 0.5 mL)	Suspension	Intramuscular	Sanofi Pasteur Limited	2007-10-04	Not applicable
Pentacel	Haemophilus influenzae type B strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen (10 ug/0.5mL) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (20 ug/0.5mL) + Bordetella pertussis fimbriae 2/3 antigen (5 ug/0.5mL) + Bordetella pertussis pertactin antigen (3 ug/0.5mL) + Bordetella pertussis toxoid antigen (glutaraldehyde inactivated) (20 ug/0.5mL) + Clostridium tetani toxoid antigen (formaldehyde inactivated) (5 [Lf]/0.5mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (15 [Lf]/0.5mL) + Poliovirus type 1 antigen (formaldehyde inactivated) (40 [D'ag'U]/0.5mL) + Poliovirus type 2 antigen (formaldehyde inactivated) (8 [D'ag'U]/0.5mL) + Poliovirus type 3 antigen (formaldehyde inactivated) (32 [D'ag'U]/0.5mL)	Injection; Injection, suspension; Kit	Intramuscular	Sanofi Pasteur Inc.	2008-06-20	Not applicable
Pentacel	Haemophilus influenzae type B strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen (10 ug/0.5mL) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (20 ug/0.5mL) + Bordetella pertussis fimbriae 2/3 antigen (5 ug/0.5mL) + Bordetella pertussis pertactin antigen (3 ug/0.5mL) + Bordetella pertussis toxoid antigen (glutaraldehyde inactivated) (20 ug/0.5mL) + Clostridium tetani toxoid antigen (formaldehyde inactivated) (5 [Lf]/0.5mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (15 [Lf]/0.5mL) + Poliovirus type 1 antigen (formaldehyde inactivated) (29 [D'ag'U]/0.5mL) + Poliovirus type 2 antigen (formaldehyde inactivated) (7 [D'ag'U]/0.5mL) + Poliovirus type 3 antigen (formaldehyde inactivated) (26 [D'ag'U]/0.5mL)	Injection; Injection, suspension; Kit	Intramuscular	Sanofi Pasteur Inc.	2008-06-20	Not applicable
PENTAXIM 0,5 ML (IM ENJEKSİYON) SÜSPANSİYON İÇİN TOZ İÇEREN FLAKON VE SÜSPANSİYON İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADET	Haemophilus influenzae type B strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen (10 mcg/0.5ml) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (25 mcg/0.5ml) + Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) (25 mcg/0.5ml) + Clostridium tetani toxoid antigen (formaldehyde inactivated) (40 IU/0.5ml) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (30 IU/0.5ml) + Poliovirus type 1 antigen (formaldehyde inactivated) (40 DU/0.5ml) + Poliovirus type 2 antigen (formaldehyde inactivated) (8 DU/0.5ml) + Poliovirus type 3 antigen (formaldehyde inactivated) (32 DU/0.5ml)	Injection, powder, for suspension	Intramuscular	SANOFİ PASTEUR AŞI TİC. A.Ş.	2020-08-14	Not applicable
Prohibit Inj Vaccine	Haemophilus influenzae type B strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen (25 mcg / 0.5 mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (23 mcg / 0.5 mL)	Liquid	Intramuscular	Aventis Pasteur Limited	1988-12-31	2000-05-27

Chemical Identifiers

UNII: FLV5I5W26R
CAS number: Not Available

References

General References

Dailymed Label: ACTHIB- haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen [Link]

External Links

PubChem Substance: 347910467
RxNav: 1300464

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Completed	Prevention	Acute Lymphoblastic Leukemia (ALL)	1
4	Completed	Prevention	BCG Infection / Immune Responses / Vaccine Reaction	1
4	Completed	Prevention	Diphtheria / Haemophilus Influenzae Serotype b (Hib) / Meningitis / Meningococcal Infections / Pertussis / Tetanus	1
4	Completed	Treatment	Pain	1
3	Active Not Recruiting	Prevention	Meningococcal Infection (Healthy Volunteers)	1
3	Completed	Prevention	Acellular Pertussis / Diphtheria / Haemophilus Influenzae Serotype b (Hib) / Poliomyelitis / Tetanus / Viral Hepatitis B	1
3	Completed	Prevention	Bacterial Infections / Neisseria Meningitidis / Virus Diseases	1
3	Completed	Prevention	Bacterial Infections / Virus Diseases	2
3	Completed	Prevention	Diphtheria / Haemophilus Infections / Pertussis / Poliomyelitis / Tetanus	1
3	Completed	Prevention	Diphtheria / Haemophilus Influenzae Serotype b (Hib) / Pertussis / Poliomyelitis / Tetanus	4

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Kit; powder, for solution	Intramuscular
Injection, powder, for solution	Intramuscular	10 µg/0.5mL
Injection, powder, lyophilized, for solution; kit	Intramuscular	10 ug/0.5mL
Injection, powder, lyophilized, for solution	Intramuscular
Kit	Intramuscular
Suspension	Intramuscular
Injection; injection, suspension; kit	Intramuscular
Injection, powder, for suspension	Intramuscular
Liquid	Intramuscular
Injection, suspension	Intramuscular

Prices

Not Available

Patents

Not Available

Properties

State: Not Available
Experimental Properties: Not Available

Drug created at November 30, 2015 21:23 / Updated at November 28, 2021 16:22

Haemophilus influenzae type B strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen

Identification

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties