Candicidin is an antibiotic obtained from a streptomyces (Streptomyces griseus) and active against some fungi of the genus Candida (C. albicans). Candicidin is administered intravaginally in the treatment of vulvovaginal...
- Mechanism
- Curator reviewed
Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of Candicidin. Candicidin binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. There is some evidence that the binding site in the cell wall may be to fatty acids or fatty acid esters and that this binding capacity must be satisfied before candicidin can bring about its lethal effect by binding to sterol in the cell membrane.
- Primary indication
- Used in the topical treatment of vulvovaginal candidiasis.Curator reviewed
- Formula / weight
- C59H84N2O18 · 1109.317 g/mol (avg)
- Also known as
- Levorin
Resolves to
OPGSFDUODIJJGF-JBUZINEHSA-NSMILESCC(CC(C)C1OC(=O)CC(=O)CCCC(=O)CC(O)CC(O)CC(O)CC(=O)CC(O)C(C(O)CC(OC2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\C1C)C(O)=O)C(O)CC(=O)C1=CC=C(N)C=C1What you can answer from here — as of September 13, 2026
Which companies are running trials of Candicidin, in which indications and phases, and which of those programs are still active?
Create a free account or log in to explore the full data card.
Create Account