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Zileuton
go.drugbank.com/drugs/DB00744ApprovedWithdrawnBoth the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems. The immediate release tablet of Zileuton has been withdrawn from the US market. … Zileuton relieves such symptoms through its selective inhibition of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid.
Seladelpar
go.drugbank.com/drugs/DB12390ApprovedInvestigationalSeladelpar is a peroxisome proliferator-activated receptor (PPAR)-delta (δ) agonist. Seladelpar is a single enantiomer of the R-configuration. … [L51149] On August 14, 2024, seladelpar was granted accelerated approval by the FDA for the treatment of primary biliary cholangitis,[L51154] which is a condition associated with aberrant bile acid metabolism
Fluciclovine (18F)
go.drugbank.com/drugs/DB13146ApprovedInvestigationalFluciclovine is a [18F]-tagged synthetic analog of the amino acid L-leucine. It presents excellent diagnostic properties to be used in positron emission tomography (PET) imaging. … [A31384] The structure of fluciclovine allows it to be uptaken by the tumoral cells by its amino acid transporter without incorporating in the metabolism within the body.
Arginine
go.drugbank.com/drugs/DB00125ApprovedInvestigationalNutraceuticalAn essential amino acid that is physiologically active in the L-form.
Mixtures: AA-Ven, TRAVASOL PLUS 15% LIBRE DE BISULFITOSulfadoxine
go.drugbank.com/drugs/DB01299ApprovedInvestigationalWithdrawnA long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.
Categories: combinations of sulfonamidesElasomeran
go.drugbank.com/drugs/DB15654ApprovedInvestigationalat half (50 mcg) of its regular strength. … The Moderna COVID-19 Vaccine is administered as a series of two intramuscular injections, one month (28 days) apart.
Centanafadine
go.drugbank.com/drugs/DB14841ApprovedInvestigational[L63934] The FDA approved centanafadine on July 24, 2026, for the treatment of ADHD in adults and pediatric patients 6 years of age and older weighing at least 20 kg; use is not recommended below that … reuptake inhibitor, positioning it as a new mechanistic option in a condition where response varies widely between individuals and many patients remain symptomatic on existing treatment.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeFormic acid
go.drugbank.com/drugs/DB01942ApprovedInvestigationalIt is an important intermediate in chemical synthesis and occurs naturally, most famously in the venom of bee and ant stings. … It is commonly used as a preservative and antibacterial agent in livestock feed.
Mixtures: Nutri-Tab OB, Nutri-Tab OB plus DHANitrous acid
go.drugbank.com/drugs/DB09112ApprovedInvestigationalIt is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. … Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning.
Categories: Compounds used in a research, industrial, or household settingObeticholic acid
go.drugbank.com/drugs/DB05990ApprovedInvestigationalhepatic decompensation) due to a risk of liver failure, in some cases requiring liver transplantation. … Primary biliary cirrhosis, or PBC, is a progressive and chronic condition that leads to hepatic injury often resulting in end-stage liver failure that requires liver transplantation.