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Boceprevir
go.drugbank.com/drugs/DB08873ApprovedWithdrawnThe substitutions of the enzyme's catalytic triad consisting of H58, D82, and S139 are also likely to alter the affinity of the drug for NS3/4A or the activity of the enzyme itself. … The barrier for develoment of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors, another class of DAAs [A19593].
Categories: Antivirals for treatment of HCV infectionsProducts: VICTRELIS ® CAPSULAS 200 MG (MOLECULA PROTEGIDA)Aminohippuric acid
go.drugbank.com/drugs/DB00345ApprovedInvestigationalWithdrawnThe glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. [PubChem]
Categories: Compounds used in a research, industrial, or household settingDaridorexant
go.drugbank.com/drugs/DB15031ApprovedInvestigationalInsomnia is characterized by difficulties with sleep onset and/or sleep maintenance and impairment of daytime functioning. … [A244225] Daridorexant works on orexin receptors OX1R and OX2R to block the binding of orexins, which are wake-promoting neuropeptides and endogenous ligands to these receptors.
Isocarboxazid
go.drugbank.com/drugs/DB01247Approved[A31930] It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and the phobic disorders. … [T115] It was first introduced by Roche pharmaceuticals, further developed by Validus pharms Inc and first FDA approved as a prescription drug on July 1st, 1959.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeNormethadone
go.drugbank.com/drugs/DB11609ApprovedIllicitNormethadone is used as an opioid antitussive in combination with DB11610. It is marketed in Canada by Valeant under the tradename Cophylac.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeLevacetylmethadol
go.drugbank.com/drugs/DB01227ApprovedWithdrawnLevacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. … Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well.[L44052,T862]
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeFenpropidin
go.drugbank.com/drugs/DB12728ApprovedWithdrawnFenpropidin has been investigated for the treatment of Hernia.
Categories: Compounds used in a research, industrial, or household settingTirzepatide
go.drugbank.com/drugs/DB15171ApprovedInvestigational[A246260] Its protein sequence was based on the sequence of endogenous GIP, and its pharmacological action on GLP-1 receptors is comparable to endogenous GIP; however, the long half-life of tirzepatide … [L48766] On September 15, 2022, tirzepatide was also approved by the European Commission.[L44386]. On November 02, 2023, tirzepatide was also approved by the Health Canada [L52800]
Categories: Receptors, G-Protein-CoupledProducts: Mounjaro 5 mg solution for injection in vial, Mounjaro 10 mg solution for injection in vialFollitropin
go.drugbank.com/drugs/DB00066ApprovedInvestigationalStructural analysis shows that the amino acid sequence of follitropin beta is identical to that of natural human follicle stimulating hormone (FSH). … Follitropin is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta
Categories: Sex Hormones and Modulators of the Genital SystemLithium citrate
go.drugbank.com/drugs/DB14507ApprovedInvestigationalCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome