Normethadone

DB11609ApprovedIllicitSmall moleculeAntitussive Agents

Normethadone is an opioid antitussive used to treat a cough associated with inflamed mucosa. It is marketed in Canada by Valeant under the tradename Cophylac.

Mechanism: Normethadone activates central opioid receptors in the medulla to supress the cough reflex. It also likely activates peripheral opioid receptors to inhibit signalling by irritant receptors of the airway.
Curator reviewed · 1 reference
Primary indication: For use in the treatment of cough when other less potent treatments have failed.Curator reviewed
Formula / weight: C₂₀H₂₅NO · 295.426 g/mol (avg)
First approval: Canada, 2019
Also known as: Desmethylmethadone · Isomethadone I
Code names: Hoechst 10582 · IDS-NN-007 · J5.915C · NSC-19598
Brand names: Cophylac

Resolves to

Compound

UNIIKR2L2A68XLCAS467-85-6ChEMBLCHEMBL346331ChEBI135242PubChem10090KEGGD07384

Clinical / RWD

RxNorm32009ATCR05DA06

Structure

InChIKeyWCJFBSYALHQBSK-UHFFFAOYSA-NSMILESCCC(=O)C(CCN(C)C)(C1=CC=CC=C1)C1=CC=CC=C1

What you can answer from here — as of August 30, 2026

921Drug interactionsStructured to mechanism, not free text

24ContraindicationsEach with its own population and attribute set

3Marketed productsAcross 1 country and 3 labellers

1ATC codeIncluding every combination product, plus 13 drug categories

1+ReferenceStructured and connected to the statements they support

Which companies are running trials of Normethadone, in which indications and phases, and which of those programs are still active?

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