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Indalpine
go.drugbank.com/drugs/DB08953ApprovedWithdrawnIndalpine was one of the first selective serotonin reuptake inhibitors to reach the American market. It was initially marketed by Pharmuka. However, after the emergence of widespread concern regarding adverse effects caused by SSRIs, and...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsFluocortolone
go.drugbank.com/drugs/DB08971ApprovedWithdrawnFluocortolone is a glucocorticoid with anti-inflammatory activity used topically for various skin disorders.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersDiosmin
go.drugbank.com/drugs/DB08995ApprovedInvestigationalChronic venous insufficiency is a common condition the western population. Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease. Diosmin is a bio...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP2C9 InhibitorsCarbazochrome
go.drugbank.com/drugs/DB09012ApprovedWithdrawnCarbazochrome is a hemostatic agent that promotes clotting, preventing blood loss from open wounds. It is an oxidation product of adrenaline which enhances the microcirculatory tone . In the future this may prevent excessive blood flow d...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsSiltuximab
go.drugbank.com/drugs/DB09036ApprovedInvestigationalSiltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound I...
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersCeritinib
go.drugbank.com/drugs/DB09063ApprovedInvestigationalCeritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy. About 4% o...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesCobicistat
go.drugbank.com/drugs/DB09065ApprovedInvestigationalCobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by in...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesTasimelteon
go.drugbank.com/drugs/DB09071ApprovedInvestigationalTasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesBioallethrin
go.drugbank.com/drugs/DB13746ApprovedWithdrawnBioallethrin refers to a mixture of two of the allethrin isomers (1R,trans;1R and 1R,trans;1S) in an approximate ratio of 1:1, where both isomers are active ingredients. A mixture of the two same stereoisomers, but in an approximate rati...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesLidoflazine
go.drugbank.com/drugs/DB13766ApprovedCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates