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Trovafloxacin
go.drugbank.com/drugs/DB00685ApprovedWithdrawnDue to its hepatotoxic potential, trovafloxacin was withdrawn from the market. … It was shown to be more effective against Gram-positive bacteria than Gram-negative bacteria when compared to previous fluoroquinolones.
Medroxyprogesterone acetate
go.drugbank.com/drugs/DB00603ApprovedInvestigational[A14848] MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prevent pregnancy, … Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties.
Categories: Sex Hormones and Modulators of the Genital SystemProducts: ACETATO DE MEDROXIPROGESTERONA SUSPENSION INYECTABLE 150MGPatisiran
go.drugbank.com/drugs/DB14582ApprovedIt is marketed as Onpattro which is formulated as patisiran within a liposome envelope for better delivery to the liver, where transthyretin is produced. … The approval for Onpattro was granted to Alnylam Pharmaceuticals, Inc. in August of 2018. Onpattro has been granted Fast Track, Priority Review and Breakthrough Therapy, and Orphan Drug designations.
Capmatinib
go.drugbank.com/drugs/DB11791ApprovedInvestigational[L13347] The presence of the mutation must be confirmed by an FDA-approved test, such as the FoundationOne CDx assay (manufactured by Foundation Medicine, Inc.), which was approved by the FDA on the same … -naive patients with NSCLC has been reported to be 1.4% - 21%.
Pegvaliase
go.drugbank.com/drugs/DB12839ApprovedInvestigationalThe primary goal of lifelong treatment of PKU, as recommended by the American College of Medical Genetics and Genomics (ACMG) guidelines, is to maintain blood Phe concentration in the range of 120 µmol … /L to 3690 µmol/L [A33286].
Leucovorin
go.drugbank.com/drugs/DB00650ApprovedInvestigational[A275451] It is primarily indicated for "leucovorin rescue" to diminish the hematologic and mucosal toxicity of high-dose methotrexate therapy in osteosarcoma and to treat inadvertent overdoses of folic … [L56091, L56092] Additionally, it is used in combination with 5-fluorouracil (5-FU) to enhance therapeutic efficacy in the palliative treatment of advanced colorectal cancer and to treat megaloblastic
Products: FOLINATO DE CALCIO 50 MG, CALCIUMFOLINAT HE 100MG/10Benzgalantamine
go.drugbank.com/drugs/DB19353ApprovedInvestigational[L51564] Benzgalantamine was approved by the FDA in July 2024 for the treatment of mild-to-moderate dementia in Alzheimer's patients.[L51534,L51564] … [A264454] As a prodrug, benzagalantamine remains inert as it passes through the stomach, thereby avoiding many of the gastrointestinal effects associated with peripheral cholinesterase inhibition.
Sodium hydroxide
go.drugbank.com/drugs/DB11151ApprovedAccording to the the FDA, sodium hydroxide is considered a direct food recognized as safe, where it serves as a pH control agent and follows good manufacturing guidelines [L1967]. … The use of this compound has been shown to effectively reduce prion levels in an in vitro inactivation assay [A32334].
Mixtures: AMINOPLASMAL® 10% E, AMINOPLASMAL® 10% ESirolimus
go.drugbank.com/drugs/DB00877ApprovedInvestigational[A242372] The topical formulation of sirolimus, marketed as HYFTOR, was approved by the FDA in April 2022: this marks the first topical treatment approved in the US for facial angiofibroma associated with … [A242372] In November 2000, the drug was recognized by the European Agency as an alternative to calcineurin antagonists for maintenance therapy with corticosteroids.
Products: LIKMUN-E, RENACEPTNaratriptan
go.drugbank.com/drugs/DB00952ApprovedNaratriptan is a triptan drug that is selective for the 5-hydroxytryptamine1 receptor subtype. It is typically used for the treatment of migraine headaches.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Serotonin Receptor Agonists