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Displaying results 1981 - 1990 of 10000 in total
  1. Drug

    Nonoxynol-9

    go.drugbank.com/drugs/DB06804
    ApprovedWithdrawn

    Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. … N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams, gels, foams and condom lubricants.

    Synonyms: Nonoxynol 9, Nonoxynol-9Categories: Compounds used in a research, industrial, or household setting
  2. Drug

    Plicamycin

    go.drugbank.com/drugs/DB06810
    ApprovedWithdrawn

    Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus.

    Categories: Compounds used in a research, industrial, or household setting
  3. Drug

    Pralatrexate

    go.drugbank.com/drugs/DB06813
    ApprovedInvestigational

    [A246693] Pralatrexate is designed to have a higher affinity for the reduced folate carrier, a protein that is overexpressed in malignant cells and is upregulated by oncogenes. … [A246703] As such, pralatrexate is thought to have a better therapeutic window compared to other antifolate analogs due to the novel target of RFC.

    Synonyms: (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}amino)pentanedioic acid, (2S)-2-((4-((1RS)-1-((2,4-Diaminopteridin-6-yl)methyl)but-3-ynyl)benzoyl)amino)pentanedioic acidCategories: Heterocyclic Compounds, 2-Ring
  4. Drug

    CHIR-124

    go.drugbank.com/drugs/DB06852
    Experimental

    CHIR-124 is a potent inhibitor of Chk1 that potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo.

    Categories: Heterocyclic Compounds, 2-Ring
  5. Drug

    (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide

    go.drugbank.com/drugs/DB06941
    Experimental

    (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide is a solid. This compound belongs to the phenylpiperazines. … These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group. This drug targets the protein S100B.

    Synonyms: (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide
  6. Drug

    N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-L-prolinamide

    go.drugbank.com/drugs/DB06942
    Experimental

    N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-l-prolinamide is a solid. This compound belongs to the alpha amino acid amides. These are amide derivatives of alpha amino acids.

    Synonyms: N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-L-prolinamide
  7. Drug

    JNJ-27390467

    go.drugbank.com/drugs/DB06962
    Experimental

    JNJ-27390467 is a potent, nonpeptide inhibitor of human mast cell tryptase.

  8. Drug

    Paratoulene phosphate

    go.drugbank.com/drugs/DB04495
    Experimental

    Categories: Heterocyclic Compounds, 1-Ring
  9. Drug

    5-Nitroindazole

    go.drugbank.com/drugs/DB04534
    Experimental

    Synonyms: 5-Nitroindazole, 5-Nitro-1H-indazoleCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  10. Drug

    1-benzylimidazole

    go.drugbank.com/drugs/DB04581
    Experimental

    1-benzylimidazole, an N-imidazole derivative, has been shown to have strong cardiotonic activity.

    Synonyms: 1-benzylimidazole, 1-benzyl-1H-imidazoleCategories: Heterocyclic Compounds, 1-Ring