Nonoxynol-9

DB06804ApprovedWithdrawnSmall molecule

Nonoxynol-9 is a vaginal spermicide used for the non-hormonal contraception in conjunction with other modes of contraception. Spermicides are locally acting non-hormonal contraceptives.

Mechanism: Nonoxynol-9 interacts with the lipids in the membranes of the acrosome and the midpiece of the sperm. The sperm membranes are lysed; the acrosome, neck and midpiece of the spermatozoa are loosened and then detached which results in their immobilization and death.
Curator reviewed
Primary indication: Nonoxynol 9 is a surfactant spermicide used for contraception in spermicidal creams, jellies, foams, gel, and lubricants.Curator reviewed · 1 structured indication
Formula / weight: C₃₃H₆₀O₁₀ · 616.8235 g/mol (avg)
First approval: United States, 1983
Also known as: Nonoxynol 9 · PEG-9 nonyl phenyl ether · Tergitol NP-9
Brand names: Conceptrol
Gynol II
Today Sponge
Vcf Contraceptive

Resolves to

Compound

UNII48Q180SH9TCAS26027-38-3ChEMBLCHEMBL1410ChEBI53775PubChem72385KEGGD06490

Clinical / RWD

RxNorm53750PharmGKBPA450648

Structure

InChIKeyFBWNMEQMRUMQSO-UHFFFAOYSA-NSMILESCCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1

What you can answer from here — as of June 30, 2026

113Drug interactionsStructured to mechanism, not free text

8Clinical trialsPhase, status and sponsor resolved per trial

1Structured indicationCondition, population, route and combination as fields, not prose

9Marketed productsAcross 2 countries and 6 labellers

2+ReferencesStructured and connected to the statements they support

Which other approved drugs treat the same conditions as Nonoxynol-9, and which companies have late-stage candidates in those indications?

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