Search

Displaying results 1981 - 1990 of 10000 in total
  1. Drug

    Mipicoledine

    go.drugbank.com/drugs/DB15075
    Investigational

    Mipicoledine is under investigation in clinical trial NCT01048008 (Study of 4-Demethylcholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) in Patients With Advanced Cancer).

    Synonyms: (3.BETA.)-CHOLEST-5-EN-3-YL 3,5-DICHLORO-2-METHOXY-6-(TRICHLOROMETHYL)PYRIDIN-4-YL CARBONATE, CHOLEST-5-EN-3.BETA.-YL 3,5-DICHLORO-2-METHOXY-6-(TRICHLOROMETHYL)PYRIDIN-4-YL CARBONATECategories: P-glycoprotein substrates
  2. Drug

    Gunagratinib

    go.drugbank.com/drugs/DB18191
    Experimental

    Synonyms: (s)-1-(1-acryloylpyrrolidin-3-yl)-3-((3,5-dimethoxyphenyl)ethynyl)-5-(methylamino)-1h-pyrazole-4-carboxamide, 1h-pyrazole-4-carboxamide, 3-(2-(3,5-dimethoxyphenyl)ethynyl)-5-(methylamino)-1-((3s)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl)-Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  3. Drug

    Repotrectinib

    go.drugbank.com/drugs/DB16826
    ApprovedInvestigational

    [A262056] ROS1 mutations are one of the defined oncogenic drives of NSCLC, and the solvent-front mutation ROS1 G2032R is responsible for 50 to 60% of [crizotinib]-resistant cases. … This approval is based on favorable results from the TRIDENT-1 study, where the objective response rate was 79% in TKI-naive patients and 38% in TKI-pretreated patients respectively.[L48741]

    Categories: Heterocyclic Compounds, 1-Ring, Antineoplastic and Immunomodulating AgentsSynonyms: (3R,6S,)-45-FLUORO-3,6-DIMETHYL-5-OXA-2,8-DIAZA-1(5,3)-PYRAZOLO(1,5-A)PYRIMIDINA-4(1,2)-BENZENANONAPHAN-9-ONE, 1,15-ETHENO-1H-PYRAZOLO(4,3-F)(1,4,8,10)BENZOXATRIAZACYCLOTRIDECIN-4(5H)-ONE, 11-FLUORO-6,7,13,14-TETRAHYDRO-7,13-DIMETHYL-, (7S,13R)-
  4. Drug

    Carboplatin

    go.drugbank.com/drugs/DB00958
    ApprovedInvestigational

    [A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]

    Categories: Compounds used in a research, industrial, or household setting, Indicators and ReagentsSynonyms: Platinum, diammine [1,1-cyclobutane-dicarboxylato(2-)-0,0']-,(SP-4-2)
  5. Drug

    Olanzapine

    go.drugbank.com/drugs/DB00334
    ApprovedInvestigational

    [A176996] Its chemical structure contains a thieno[2,3-b][1,5]benzodiazepine core, and has a methyl group attached to the piperazine ring. … Olanzapine is a thienobenzodiazepine derivative and an atypical or second-generation antipsychotic agent.

    Synonyms: 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepineInternational brands: Jolyon-MD
  6. Drug

    MMDA

    go.drugbank.com/drugs/DB01442
    ExperimentalIllicit

    MMDA, or 3-methoxy-4,5-methylenedioxyamphetamine, is a member of the amphetamine drug class with stimulant and psychedelic properties. It also acts as an entheogen and an entactogen. … The effects of MMDA includes feelings of euphoria and warmth, as well as realistic closed-eye visuals.

    Synonyms: 5-Methoxy-3,4-methylenedioxyamphetamine, 3-methoxy-methylenedioxyamphetamineCategories: Serotonin 5-HT2 Receptor Agonists, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates
  7. Drug

    Quemliclustat

    go.drugbank.com/drugs/DB19160
    Investigational

    Quemliclustat is under investigation in clinical trial NCT05329766 (A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal

    Synonyms: 1h-pyrazolo(3,4-b)pyridin-4-amine, 6-chloro-n-((1s)-1-(2-fluorophenyl)ethyl)-1-(5-o-(hydroxy(phosphonomethyl)phosphinyl)-.beta.-d-ribofuranosyl)-, 2-chloro-n6 -((1s)-1-(2-fluorophenyl)ethyl)-8-aza-1,7- dicarbaadenosine 5'-(trihydrogen 2-carbadiphosphate)Categories: Heterocyclic Compounds, 1-Ring
  8. Drug

    RS-39604

    go.drugbank.com/drugs/DB17050
    Experimental

    RS-39604 is a selective 5-HT4 receptor antagonist.[A253112]

    Categories: Heterocyclic Compounds, 1-RingSynonyms: Methanesulfonamide, n-(2-(4-(3-(4-amino-5-chloro-2-((3,5-dimethoxyphenyl)methoxy)phenyl)-3-oxopropyl)-1-piperidinyl)ethyl)-
  9. Drug

    3-Methyl-5-(7-{4-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]phenoxy}heptyl)-1,2-oxazole

    go.drugbank.com/drugs/DB08727
    Experimental

    3-Methyl-5-(7-{4-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]phenoxy}heptyl)-1,2-oxazole is a solid. This compound belongs to the phenol ethers. … These are aromatic compounds containing an ether group substituted with a benzene ring. 3-Methyl-5-(7-{4-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]phenoxy}heptyl)-1,2-oxazole is known to target genome

    Synonyms: 3-Methyl-5-(7-{4-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]phenoxy}heptyl)-1,2-oxazole
  10. Drug

    Arterolane

    go.drugbank.com/drugs/DB19027
    Investigational

    Arterolane is under investigation in clinical trial NCT03452475 (Comparison of Arterolane-piperaquine Versus Arterolane-piperaquine+mefloquine Versus Artemether-lumefantrine in Kenyan Children).

    Synonyms: Dispiro(cyclohexane-1,3'-(1,2,4)trioxolane-5',2''-tricyclo(3.3.1.13,7)decane)-4-acetamide, n-(2-amino-2-methylpropyl)-, cis-Categories: arterolane and piperaquine, Antiparasitic Products, Insecticides and Repellents