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Displaying results 11 - 20 of 151542 in total
  1. Drug

    Seladelpar

    go.drugbank.com/drugs/DB12390
    ApprovedInvestigational

    Seladelpar works to block bile acid synthesis.[A264234] … [L51149] On August 14, 2024, seladelpar was granted accelerated approval by the FDA for the treatment of primary biliary cholangitis,[L51154] which is a condition associated with aberrant bile acid metabolism

    Synonyms: ACETIC ACID, (4-(((2R)-2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)THIO)-2-METHYLPHENOXY)- ((4-(((2R)-2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)THIO)-2-METHYLPHENYL)OXY)ACETIC ACID, ((4-(((2R)-2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)THIO)-2-METHYLPHENYL)OXY)ACETIC ACIDCategories: Bile and Liver Therapy, Alimentary Tract and Metabolism
  2. Drug

    Etacrynic acid

    go.drugbank.com/drugs/DB00903
    ApprovedInvestigational

    A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. … This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.

    Categories: etacrynic acid, Aryloxyacetic Acid DerivativesSynonyms: (2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy)acetic acid, Etacrinic acid
  3. Drug

    Gossypol acetic acid

    go.drugbank.com/drugs/DB31699
    Investigational

    Synonyms: Gossypol acetic acid, (±)-gossypol acetic acid
  4. Drug

    Tienilic acid

    go.drugbank.com/drugs/DB04831
    ApprovedWithdrawn

    Tienilic acid, or ticrynafen, is a diuretic drug with uric acid-lowering action which was marketed for the treatment of hypertension. … It was withdrawn in 1982 after case reports in the United States suggested a link between ticrynafen and hepatitis. (Manier et al., 1982)

    Categories: tienilic acid, Aryloxyacetic Acid DerivativesSynonyms: (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid, (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid
  5. Drug

    Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen

    go.drugbank.com/drugs/DB16709
    Approved

    Sheets containing this scaffold product are applied to the burn site and, as they contain metabolically active and viable cells, provide a variety of human growth factors and cytokines as well as extracellular … Stratagraft (allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen-dsat) is an allogeneic cellularized scaffold product used for the treatment of adults with thermal burns containing

    Synonyms: Viable and metabolically active allogeneic human NIKS keratinocytes and human dermal fibroblasts cellularized layered scaffold, Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen
  6. Drug

    Acetylamino-Acetic Acid

    go.drugbank.com/drugs/DB02713
    Experimental

  7. Drug

    Sulindac

    go.drugbank.com/drugs/DB00605
    ApprovedInvestigational

    Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. … Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes.

    Categories: Acetic Acid Derivatives and Related Substances, Antiinflammatory and Antirheumatic ProductsSynonyms: cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid, (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
  8. Drug

    Sodium acetate

    go.drugbank.com/drugs/DB09395
    ApprovedInvestigational

    It can be used also in metabolic acidosis and for urine alkalinization. … Sodium acetate could be used as additives in food, industry, concrete manufacture, heating pads and in buffer solutions.

    Synonyms: acetic acid, sodium salt, Acetic acid, sodium salt (1:1)Mixtures: Plasma-Lyte 148 and dextrose, Normosol-R and Dextrose
  9. Drug

    Zomepirac

    go.drugbank.com/drugs/DB04828
    ApprovedWithdrawn

    The manufacturer voluntarily removed Zomax tablets from the Canadian, US, and UK markets in March 1983. … Zomepirac, formerly marketed as Zomax tablets, was associated with fatal and near-fatal anaphylactoid reactions.

    Synonyms: 5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic acidCategories: Acetic Acid Derivatives and Related Substances, Antiinflammatory and Antirheumatic Products
  10. Drug

    Indomethacin

    go.drugbank.com/drugs/DB00328
    ApprovedInvestigational

    -3-acetic acid. … Indometacin was first discovered in 1963 and it was first approved for use in the U.S. by the Food and Drug Administration in 1965, [A486] along with other acetic acid derivatives such as [diclofenac]

    Synonyms: 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid, {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acidCategories: Acetic Acid Derivatives and Related Substances, indometacin and antiinfectives