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Fluconazole Action Pathway
smpdb.ca/view/SMP0125079Drug actionThis enzyme catalyzes the reaction of lanosterol with 3 oxygen and 3 NADPH to become 4,4-Dimethylcholesta-8,14,24-trienol with byproducts of formic acid, 4 hydrogen ions, 4 water, and 3 NADP+. … Fluconazole, known commonly as the brand name Driflucan, is an antifungal drug taken mainly orally in the form of a pill, but can also be applied topically.
Itraconazole Action Pathway
smpdb.ca/view/SMP0125099Drug actionThis enzyme catalyzes the reaction of lanosterol with 3 oxygen and 3 NADPH to become 4,4-Dimethylcholesta-8,14,24-trienol with byproducts of formic acid, 4 hydrogen ions, 4 water, and 3 NADP+.
Econazole Action Pathway
smpdb.ca/view/SMP0125404Drug actionThis enzyme catalyzes the reaction of lanosterol with 3 oxygen and 3 NADPH to become 4,4-Dimethylcholesta-8,14,24-trienol with byproducts of formic acid, 4 hydrogen ions, 4 water, and 3 NADP+.
Itraconazole Metabolism
smpdb.ca/view/SMP0125100MetabolicItraconazole is taken mainly in a pill form. The oral bioavailability of itraconazole is only 55% and is best when taken with food.
Ketoconazole Anti-fungal Action Pathway
smpdb.ca/view/SMP0125162Drug actionKetoconazole is an antifungal imidazole, known as the brand name Extina, Ketodan, Ketoderm, Nizoral, Xolegel. It is typically applied as a topical cream since there are now better oral anti-fungal drugs with less side-effects. Ketoconazo...
Oxiconazole Action Pathway
smpdb.ca/view/SMP0125405Drug actionOxiconazole is a topical antifungal agent, known as the brand name Oxistat, that is used to treat a variety of skin fungal infections such as athlete's foot, jock itch, and ringworm.It is used to treat a number of different yeasts and de...
Terconazole Action Pathway
smpdb.ca/view/SMP0125439Drug actionThe drug comes in a cream or suppository form with high levels of safety, efficacy, and tolerability for both.
Tioconazole Action Pathway
smpdb.ca/view/SMP0125440Drug actionThrough unknown mechanisms, tioconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair
Voriconazole Action Pathway
smpdb.ca/view/SMP0125441Drug actionVoriconazole is a triazole antifungal agent used to treat invasive fungal infections, generally seen in patients who are immunocompromised. It has an increased affinity to 14-alpha sterol demethylase, and therefore makes it useful agains...
Luliconazole Action Pathway
smpdb.ca/view/SMP0125821Drug actionLuliconazole is a topical antifungal agent used to treat fungal infections. Luliconazole is a topical antifungal agent that acts by unknown mechanisms but is postulated to involve altering the synthesis of fungi cell membranes. It was ap...