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Budesonide
go.drugbank.com/drugs/DB01222ApprovedInvestigationalBudesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis. Budesonide was granted FDA approval o...
Mixtures: SYMBICORT PI 80/4.5UG120ED, SYMBICORT PI 80/4.5UG120EDCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesAzathioprine
go.drugbank.com/drugs/DB00993ApprovedInvestigationalAzathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index. Azathioprine is us...
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: Nu-azathioprine, AZATHIOPRIN DURA N 25MGBrimonidine
go.drugbank.com/drugs/DB00484ApprovedInvestigationalBrimonidine is an alpha-adrenergic agonist and 2-imidazoline derivative that was first introduced in 1996. It is considered to be a third generation alpha-2 aadrenergic receptor agonist, since it displays preferential binding at alpha-2 ...
Mixtures: Brim-Dor PF, Tim-Brim-Dor PFProducts: Alphagan P, ALPHAGAN PApixaban
go.drugbank.com/drugs/DB06605ApprovedInvestigationalApixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. ...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: Nb-apixaban, Nb-apixaban TabletWarfarin
go.drugbank.com/drugs/DB00682ApprovedInvestigationalWarfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: Nu-warfarinAcyclovir
go.drugbank.com/drugs/DB00787ApprovedInvestigationalAcyclovir is a deoxynucleoside analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis. Acyclovir is generally used first line in the treatment of these viruses and so...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: ACIC 250 PI VIA, ACIC 500 PI VIAAtazanavir
go.drugbank.com/drugs/DB01072ApprovedInvestigationalAtazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class.
Mixtures: ATAZOR-R (Atazanavir 300mg/Ritonavir 100mg) Film Coated TabletCategories: atazanavir and ritonavir, P-glycoprotein inducersBuprenorphine
go.drugbank.com/drugs/DB00921ApprovedIllicitInvestigationalVet approvedCombination with naloxone is intended to reduce the abuse potential of Suboxone, as naloxone is poorly absorbed by the oral route (and has no effect when taken orally), but would reverse the opioid agonist
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: 2-(N-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6α-yl)-3,3-dimethyl-2-butanolGlucosamine
go.drugbank.com/drugs/DB01296ApprovedOsteoarthritis (OA) is a progressive and degenerative joint disease marked by loss of cartilage, bone changes, and synovial membrane inflammation. Treatment with chondroprotective drugs, such as glucosamine sulfate may offer additional b...
Products: Nn Bio-Glucosamine 500 Tablet, Nn Glucosamine vegetable capsule 500mgAmitriptyline
go.drugbank.com/drugs/DB00321ApprovedInvestigationalAmitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in...
Mixtures: Sentravil PM-25Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates