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Displaying results 2001 - 2010 of 10000 in total
  1. Drug

    Opicapone

    go.drugbank.com/drugs/DB11632
    ApprovedInvestigational

    Exhibiting a long duration of action that exceeds 24 hours, opicapone can be administered once-daily [L2336] and demonstrates the lowest risk for cytotoxicity compared to other catechol-O-methyltransferase … of these symptoms through the use of a dopamine agonist, a monoamine oxidase B inhibitor (selegiline, rasagiline), a _catechol-O-methyl transferase (COMT)_ inhibitor, or amantadine, or using a modified-release

    Categories: P-glycoprotein substrates, Cytochrome P-450 CYP1A2 Inhibitors
  2. Drug

    Dibotermin alfa

    go.drugbank.com/drugs/DB11639
    ApprovedInvestigational

    Dibotermin alfa is a recombinant human bone morphogenetic protein-2 (rhBMP-2) derived from a recombinant Chinese Hamster Ovary (CHO) cell line [FDA Label]. … BMP-2 is a potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into osteoblasts, thus promoting bone and cartilage formation [A31952].

    Synonyms: BMP 2, BMP-2
  3. Drug

    Amifampridine

    go.drugbank.com/drugs/DB11640
    Approved

    Patients with LEMS develop serum antibodies against presynaptic P/Q-type voltage-gated calcium channels, leading to decreased presynaptic calcium levels and reduced quantal release of acetylcholine, which … In phase III clinical trials of adult patients with LEMS, treatment of amifampridine significantly improved symptoms of LEMS compared to placebo with good tolerance [A33864].

    Categories: Heterocyclic Compounds, 1-Ring
  4. Drug

    HT-0712

    go.drugbank.com/drugs/DB11650
    Investigational

    BLX-028914 has been used in trials studying the treatment and basic science of Allergic Rhinitis and Age-Associated Memory Impairment (AAMI).

    Categories: Heterocyclic Compounds, 1-Ring
  5. Drug

    Dactolisib

    go.drugbank.com/drugs/DB11651
    Investigational

    Dactolisib has been used in trials studying the treatment of Cancer, Solid Tumor, Renal Cancer, Breast Cancer, and Cowden Syndrome, among others.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  6. Drug

    Rebamipide

    go.drugbank.com/drugs/DB11656
    ApprovedInvestigational

    Rebamipide has been investigated for the treatment of Stomach Ulcer, Keratoconjunctivitis Sicca, and Gastric Adenoma and Early Gastric Cancer.

    Categories: Heterocyclic Compounds, 2-Ring, Compounds used in a research, industrial, or household setting
  7. Drug

    QAV-680

    go.drugbank.com/drugs/DB11658
    Investigational

    QAV680 has been used in trials studying the treatment of Asthma, Allergic Rhinitis, and Seasonal Allergic Rhinitis.

    Categories: Heterocyclic Compounds, 2-Ring
  8. Drug

    Psilocybin

    go.drugbank.com/drugs/DB11664
    Investigational

    Psilocybin has been investigated for the treatment of Anxiety and Stage IV Melanoma. In November, 2019, it was granted Breakthrough Therapy status by the FDA.

    Categories: Heterocyclic Compounds, 2-Ring
  9. Drug

    SP-8203

    go.drugbank.com/drugs/DB11670
    Investigational

    SP-8203 has been used in trials studying the treatment of Ischemic Stroke.

    Categories: Heterocyclic Compounds, 2-Ring
  10. Drug

    AZD-4877

    go.drugbank.com/drugs/DB11671
    Investigational

    AZD4877 has been used in trials studying the treatment of NHL, Tumors, Cancer, Lymphoma, and Neoplasms, among others.

    Categories: Heterocyclic Compounds, 1-Ring