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Nicotine
go.drugbank.com/drugs/DB00184ApprovedInvestigationalNicotine is also important medically because of its presence in tobacco smoke.
Categories: Drugs Used in Addictive Disorders, Drugs Used in Nicotine DependenceSynonyms: 3-(N-methylpyrollidino)pyridine, 3-(2-(N-methylpyrrolidinyl))pyridineFinotonlimab
go.drugbank.com/drugs/DB18859InvestigationalFinotonlimab is under investigation in clinical trial NCT04560894 (SCT-I10A Plus SCT510 Versus Sorafenib as First-line Therapy for Advanced Hepatocellular Carcinoma).
Tezacaftor
go.drugbank.com/drugs/DB11712ApprovedInvestigational[L1595] It was developed by Vertex Pharmaceuticals and FDA approved in combination with [ivacaftor] to manage cystic fibrosis.[L6814] This drug was approved by the FDA on February 12, 2018. … CFTR is active in epithelial cells of organs such as of the lungs, pancreas, liver, digestive system, and reproductive tract.
Sotagliflozin
go.drugbank.com/drugs/DB12713ApprovedInvestigational[L39734] A similar approval has also been sought in the US, but the FDA has since published a proposal to refuse the approval because the data submitted did not show that it was safe under the proposed … [L46616] In May 2023, sotagliflozin was approved by the FDA to reduce the risk of cardiovascular death and heart failure in patients with high risk factors.[]
Categories: Drugs Used in DiabetesPropiverine
go.drugbank.com/drugs/DB12278ApprovedOAB has a negative impact on quality of life and may lead to leakage and inconvenient urinary accidents [L2327], [L2328]. … Overactive bladder syndrome affects millions of elderly individuals in the United States and shows equal prevalence in men and women.
Opicapone
go.drugbank.com/drugs/DB11632ApprovedInvestigationalOpicapone was approved for use by the European Commission in June 2016 [L2339] and the FDA in April 2020.[L13772] It is marketed under the brand name Ongentys as once-daily oral capsules. … [L2336] Opicapone is used for adjunct therapy to levodopa and carbidopa in adult patients with Parkinson's disease and end-of-dose motor fluctuations.
Rilpivirine
go.drugbank.com/drugs/DB08864ApprovedInvestigational[L1031] Rilpivirine in combination with [cabotegravir] was granted FDA approval on 21 January 2021. … [A31331] Rilpivirine was developed by Tilbotec, Inc. and FDA approved on May 20, 2011.
Categories: Antivirals used in combination for the treatment of HIV infectionsSynonyms: 4-{[4-({4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile19-norandrostenedione
go.drugbank.com/drugs/DB01434ExperimentalIllicitAfter 2005, 19-Norandrostenedione was regulated in the United States as a schedule III controlled substance, as well as banned from use in competitive sports by the World Anti-Doping Agency. … In the body 19-norandrostenedione is rapidly metabolized into [nandrolone], also known as nortestosterone.
Norelgestromin
go.drugbank.com/drugs/DB06713ApprovedInvestigationalNorelgestromin was first approved in the United States in 2001 as the progestin in a norelgestromin and ethinyl estradiol transdermal contraceptive system.[L63816] … Norelgestromin is a progestin used as the progestational component of combined hormonal contraceptives.
Quizartinib
go.drugbank.com/drugs/DB12874ApprovedInvestigational[A260641] Quizartinib was approved by the FDA in July 2023 and developed under the brand name VANFLYTA by Daiichi Sankyo. … Quizartinib is an oral and potent fms-like tyrosine kinase 3 (FLT3) inhibitor and it is the first drug developed specifically targeting FLT3, as other agents with FLT3 inhibition activities were investigated
Synonyms: N-(5-(1,1-Dimethylethyl)isoxazol-3-yl)-N'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)urea