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Displaying results 2021 - 2030 of 10000 in total
  1. Drug

    Uridine triacetate

    go.drugbank.com/drugs/DB09144
    Approved

    It is provided in the prodrug form as uridine triacetate as this form delivers 4- to 6-fold more uridine into the systemic circulation compared to equimolar doses of uridine itself. … Additionally, orotic acid from the de novo pyrimidine pathway that cannot be converted to UMP is excreted in the urine, accounting for the common name of the disorder, orotic aciduria.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 2',3',5'-tri-O-acetyluridine, 2',3',5'-Triacetyluridine
  2. Drug

    Difelikefalin

    go.drugbank.com/drugs/DB11938
    ApprovedInvestigational

    [A237610] These revelations led to the study of KOR agonists as a potential treatment option in patients suffering from pruritic conditions. … [A237615,A237620] The clinical burden of uremic pruritus in this patient population is being increasingly recognized as contributing to a significant reduction in patient quality of life, poor outcomes

    Categories: Heterocyclic Compounds, 1-Ring
  3. Drug

    Meradimate

    go.drugbank.com/drugs/DB11096
    Approved

    [T200] It is currently required to be named as meradimate in all FDA approved OTC products. Meradimate is approved by the FDA and Health Canada to be used as an ingredient in sunblocking products. … Meradimate, before known as menthyl anthranilate, is used in a maximal concentration of 5% in different products as a UV filter.

    Mixtures: Herpecin L, Herpecin LSynonyms: Menthyl-O-aminobenzoate
  4. Drug

    Acetyl sulfisoxazole

    go.drugbank.com/drugs/DB14033
    ApprovedVet approved

    It is often combined with erythromycin to treat acute otitis media caused by the bacteria, haemophilus influenzae [L2790]. … Sulfisoxazole acetyl competes with PABA for the bacterial enzyme, _dihydropteroate synthase_, preventing the incorporation of PABA into dihydrofolic acid, which is the precursor of folic acid.

    Categories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
  5. Drug

    Amantadine

    go.drugbank.com/drugs/DB00915
    ApprovedInvestigational

    An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. … The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

    Mixtures: ROSEL-T, Innoprax-5Categories: Influenza A M2 Protein Inhibitor, Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
  6. Drug

    Fluoroestradiol F-18

    go.drugbank.com/drugs/DB15690
    ApprovedInvestigational

    [L14117] It is expected to be available in late 2020/early 2021.[L14117] … Fluoroestradiol F-18 is an imaging agent used with positron emission tomography (PET) to detect estrogen receptor-positive breast cancer lesions.

    Synonyms: F-18 Fes, Fes F-18
  7. Drug

    Lumefantrine

    go.drugbank.com/drugs/DB06708
    ApprovedInvestigational

    </i> and may be used to treat infections caused by <i>P. falciparum</i> and unidentified <i>Plasmodium</i> species, including infections acquired in chloroquine-resistant areas. … This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.

    Mixtures: KOMEFAN ® 280, ARTEMETERO Y LUMEFANTRINACategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Inhibitors
  8. Drug

    Fluoxetine

    go.drugbank.com/drugs/DB00472
    ApprovedInvestigationalVet approved

    [A181673] It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies … Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI).

    Mixtures: TARGET 3 MG /25 MG KAPSUL, 90 ADET, TARGET 6 MG /25 MG KAPSUL, 90 ADETCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, P-glycoprotein inhibitors
  9. Drug

    Xenon Xe-129

    go.drugbank.com/drugs/DB17386
    ApprovedInvestigational

    Hyperpolarized Xenon-129 (Xe-129) is a contrast agent used in the lung's clinical magnetic resonance imaging (MRI). … [Helium-3] (He-3) is the one most commonly used due to its strong signal and favorable safety profile, but its use in other applications has affected its availability.

    Synonyms: Xenon, isotope of mass 129m(8.88 d), Xenon xe-129m
  10. Drug

    Estradiol

    go.drugbank.com/drugs/DB00783
    ApprovedInvestigationalVet approved

    [DB00977] (EE) is a synthetic form of estradiol commonly used as the estrogenic component of most combination oral contraceptive pills (OCPs). … Ethinyl estradiol is different from estradiol due to its higher biovailability and increased resistance to metabolism, rendering it more suitable for oral administration.

    Mixtures: FEMOSTON CONTI 1/5, FEMOSTON CONTI 1/5 TABLETCategories: Sex Hormones and Modulators of the Genital System, P-glycoprotein substrates