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Floxuridine
go.drugbank.com/drugs/DB00322ApprovedInvestigationalWhen administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. … It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Cidofovir
go.drugbank.com/drugs/DB00369ApprovedInvestigationalIt suppresses CMV replication through selective inhibition of viral DNA synthesis. … [FDA label] It was manufactured by _Gilead_ and initially approved by the FDA in 1996, but has since been discontinued.[L6223]
Beractant
go.drugbank.com/drugs/DB06761ApprovedIt is suspended in 0.9% sodium chloride solution, and heat-sterilized. … Considered a natural source of surfactant as it is made from bovine lung extract, beractant contains a mixture of phospholipids, neutral lipids, fatty acids, and surfactant-associated proteins such as
Micafungin
go.drugbank.com/drugs/DB01141ApprovedInvestigationalIt belongs to the antifungal class of compounds known as echinocandins and exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall.
Products: MYCAMINE POWDER FOR SOLUTION FOR INFUSION 50MG/VIALNifurtimox
go.drugbank.com/drugs/DB11820ApprovedInvestigationalIt is commonly known as American Trypanosomiasis. … [L15366] The CDC estimates that approximately 8 million people in Central America, South America, and Mexico are infected with T. cruzi, without symptoms.
Ublituximab
go.drugbank.com/drugs/DB11850ApprovedInvestigationalCD20, an antigen expressed by various B and T cells, is an attractive therapeutic target in various cancers and autoimmune conditions. … It has been investigated for use in numerous B cell-dependent conditions, including chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and relapsing multiple sclerosis.
Altretamine
go.drugbank.com/drugs/DB00488ApprovedWithdrawnIt also acts as a chemosterilant for male houseflies and other insects.
Gedatolisib
go.drugbank.com/drugs/DB11896ApprovedInvestigational[L63796,L63927] The PI3K/AKT/mTOR pathway is a long-standing target in the breast cancer setting, with previously approved agents acting on a single node of it (i.e. PI3Kα, AKT, or mTORC1). … fulvestrant], with or without [palbociclib], for adults with HR-positive, HER2-negative locally advanced or metastatic breast cancer without a PIK3CA mutation detected, following progression on or after at
Pentetic acid
go.drugbank.com/drugs/DB14007ApprovedInvestigational[A32501] It is currently considered, in all the dosage forms, as a member of the list of approved inactive ingredients for drug products by the FDA.
Amorolfine
go.drugbank.com/drugs/DB09056ApprovedWithdrawnIt is not approved for the treatment of onychomycosis in the United States or Canada. … It is a topical solution for the treatment of toenail infections. Systemic treatments may be considered more effective.