Search
Delorazepam
go.drugbank.com/drugs/DB01511IllicitInvestigationalIn addition to be long acting, delorazepam is relatively potent, with 1 mg of delorazepam being the equivalent of 10 mg diazepam. It has been approved for marketing in Italy. … It is a long acting benzodiazepine which makes it superior in this sense to lorazepam which is short acting. Lorazepam is also a major active metabolite of delorazepam.
Categories: Heterocyclic Compounds, 2-RingRuxolitinib
go.drugbank.com/drugs/DB08877ApprovedInvestigational[A229883] Ruxolitinib has been investigated to treat patients with coronavirus disease 2019 (COVID-19) accompanied by severe systemic hyperinflammation. … Ruxolitinib, formerly known as INCB018424 or INC424, is an anticancer drug and a Janus kinase (JAK) inhibitor.
Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: JAKAVI 5 MG (TABLETS), JAKAVI® 10MG TABLETASDelafloxacin
go.drugbank.com/drugs/DB11943ApprovedInvestigationalDelafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections,
Categories: 4-Quinolones, Cytochrome P-450 CYP2C9 InducersAliskiren
go.drugbank.com/drugs/DB09026ApprovedInvestigational[L14018] Aliskiren has been proven to efficacious in reducing blood pressure when used alone or in conjunction with other antihypertensive agents.[A203624]
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesHalofantrine
go.drugbank.com/drugs/DB01218ApprovedWithdrawnHalofantrine has been shown to preferentially block open and inactivated HERG channels leading to some degree of cardiotoxicity.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesHexylcaine
go.drugbank.com/drugs/DB00473ApprovedWithdrawnHexylcaine has been discontinued in the US market. … It is a short acting local anesthetic that acts through inhibition of sodium channels.
Bentiromide
go.drugbank.com/drugs/DB00522ApprovedWithdrawnBentiromide is a dipeptide that is used in the bentiromide test, which is a screening test for evaluating pancreatic exocrine function and monitoring the adequacy of supplemental pancreatic therapy. … Cases of headache and gastrointestinal disturbances have been reported with the use of bentiromide. Bentiromide is currently not available in the U.S. or Canada.
Categories: Compounds used in a research, industrial, or household settingTramadol
go.drugbank.com/drugs/DB00193ApprovedInvestigational[A4269,A183842] Tramadol has also been shown to affect a number of other pain modulators within the central nervous system as well as non-neuronal inflammatory markers and immune mediators. … into active metabolites: (+)-tramadol and its primary metabolite (+)-O-desmethyl-tramadol (M1) are agonists of the μ opioid receptor while (+)-tramadol inhibits serotonin reuptake and (-)-tramadol inhibits
Mixtures: DOR-2®, AUROMYOTRAM-P ® TABLETASCategories: Serotonin 5-HT2 Receptor Antagonists, Serotonin 5-HT2C Receptor AntagonistsP2X purinoceptor 7
go.drugbank.com/bio_entities/BE0009814TargetHumansATP-gated nonselective transmembrane cation channel that requires high millimolar concentrations of ATP for activation (PubMed:17483156, PubMed:25281740, PubMed:9038151). Upon ATP binding, it rapidly opens to allow the influx of small ca...
Synonyms: ATP receptor, P2Z receptorCalcifediol
go.drugbank.com/drugs/DB00146ApprovedInvestigationalNutraceuticalIt is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients.
Mixtures: HEPATAMINE %8 500 ML(SETLI), HEPATAMINE %8 500 ML(SETSIZ)Categories: Vitamin D and Analogues