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Luliconazole
go.drugbank.com/drugs/DB08933ApprovedInvestigationalLuliconazole is a topical antifungal agent that acts by unknown mechanisms but is postulated to involve altering the synthesis of fungi cell membranes. … It was approved by the FDA (USA) in November 2013 and is marketed under the brand name Luzu. Luliconazole is also approved in Japan.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP3A InhibitorsSoybean oil
go.drugbank.com/drugs/DB09422ApprovedInvestigationalIt is used as a cooking oil and lipid emulsion for parenteral nutrition in clinical settings. Soybean oil-based lipid emulsion is the only FDA-approved lipid formulation for clinical use. … It is a complex mixture of triglycerides where per 100 g, soybean oil has 16 g of saturated fat, 23 g of monounsaturated fat, and 58 g of polyunsaturated fat.
Mixtures: Liposyn II, Liposyn IIProducts: LIPOFUNDIN 20 %N, LIPOFUNDIN 10 %NTelithromycin
go.drugbank.com/drugs/DB00976ApprovedBinding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. … It is used to treat mild to moderate respiratory infections.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsProducts: KETEK ® 400 MGRemestemcel-L
go.drugbank.com/drugs/DB13973ApprovedInvestigationalWithdrawnwith first-line therapies, putting them in a risk for poor outcomes and creating a significant clinical challenge [A31818]. … Based on its tolerability and safety profile, remestemcel-L is a promising alternative to second-line immunosuppressive agents [A31818].
Synonyms: Remestemcel-LTemoporfin
go.drugbank.com/drugs/DB11630ApprovedTemoporfin is a photosensitizing agent used in the treatment of squamous cell carcinoma of the head and neck [FDA Label]. … It was first authorized for market by the European Medicines Agency in October 2001. It is currently available under the brand name Foscan.
Categories: Sensitizers Used in Photodynamic/radiation Therapy, Heterocyclic Compounds with 4 or More RingsSynonyms: m-THPC, 2,3-dihydro-5,10,15,20-tetra(m-hydroxyphenyl)porphyrinLubiprostone
go.drugbank.com/drugs/DB01046ApprovedInvestigationalLubiprostone is a medication used in the management of idiopathic chronic constipation. … A prostaglandin E1 derivative, lubiprostone is a bicyclic fatty acid that activates ClC-2 chloride channels located on the apical side of the gastrointestinal epithelial cells.
Categories: Prostaglandins E, Miscellaneous GI DrugsProducts: MOVIPROST ® 8 MCG, อามิทีซา 8 ไมโครกรัมAsenapine
go.drugbank.com/drugs/DB06216ApprovedInvestigationalAsenapine also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use. FDA approved on August 13, 2009. … Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with
Categories: Dopamine D2 Receptor Antagonists, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeDasatinib
go.drugbank.com/drugs/DB01254ApprovedInvestigationalBCR-ABL is associated with the uncontrolled activity of the ABL tyrosine kinase and is involved in the pathogenesis of CML and 15-30% of ALL cases. … [A2226] The use of dasatinib was first approved by the FDA in 2006.[L45171,L45186]
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexSynonyms: N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamideDanaparoid
go.drugbank.com/drugs/DB06754ApprovedWithdrawnDanaparoid possesses a potent antithrombic activity that works by inhibiting activated factor X (Factor Xa) and activated factor II (Factor IIa). … The use of Orgaran™ was discontinued in the United States however it is available in several other countries including European countries and Japan.
Sulodexide
go.drugbank.com/drugs/DB06271ApprovedInvestigationalWithdrawnSulodexide is a mixture of glycosaminoglycans (GAGs) composed of dermatan sulfate (DS) and fast moving heparin (FMH).
Products: PROVENAL, VESSEL DUE F