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Displaying results 2121 - 2130 of 3730 in total
  1. Target

    Integrin alpha-M

    go.drugbank.com/bio_entities/BE0010412
    TargetHumans

    It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. … Integrin ITGAM/ITGB2 is also a receptor for ICAM1 ligand ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124).

    Synonyms: Neutrophil adherence receptor, Leukocyte adhesion receptor MO1
  2. Target

    High affinity cationic amino acid transporter 1

    go.drugbank.com/bio_entities/BE0000212
    TargetTransporterHumans

    High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues

    Synonyms: Ecotropic retrovirus receptor homolog, Ecotropic retroviral leukemia receptor homolog
  3. Drug

    Varicella zoster vaccine (live/attenuated)

    go.drugbank.com/drugs/DB10318
    ApprovedInvestigational

    Other complications also include bacterial infection, spread of the shingles rash to the eye (herpes zoster ophthalmicus) or ear, nerve palsies, or spread of VZV to non-immune persons via contact with

  4. Drug

    Ligelizumab

    go.drugbank.com/drugs/DB11856
    Investigational

    Ligelizumab is a humanized IgG1k monoclonal antibody targeted against immunoglobulin E (IgE). Similar in mechanism to omalizumab, another IgE-directed monoclonal antibody, ligelizumab has a distinct binding epitope as compared to its pee...

  5. Drug

    Chromic citrate

    go.drugbank.com/drugs/DB14526
    Experimental

  6. Target

    Hepatocyte nuclear factor 4-gamma

    go.drugbank.com/bio_entities/BE0003179
    TargetHumans

    Transcription factor. Has a lower transcription activation potential than HNF4-alpha

    Synonyms: Nuclear receptor subfamily 2 group A member 2
  7. Target

    Mediator of RNA polymerase II transcription subunit 1

    go.drugbank.com/bio_entities/BE0004382
    TargetHumans

    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the ...

    Synonyms: Thyroid receptor-interacting protein 2, Peroxisome proliferator-activated receptor-binding protein
  8. Drug

    Lenacapavir

    go.drugbank.com/drugs/DB15673
    ApprovedInvestigational

    HIV/AIDS remains an area of concern despite the introduction of numerous successful therapies, mainly due to the emergence of multidrug resistance and patient difficulty in adhering to treatment regimens. Lenacapavir is a first-in-class ...

    Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  9. Drug

    Raloxifene

    go.drugbank.com/drugs/DB00481
    ApprovedInvestigational

    Raloxifene is a second generation selective estrogen receptor modulator (SERM) that mediates anti-estrogenic effects on breast and uterine tissues, and estrogenic effects on bone, lipid metabolism, and

    Categories: Estrogen Receptor Modulators, P-glycoprotein substrates
  10. Drug

    Isoflavone

    go.drugbank.com/drugs/DB12007
    ApprovedInvestigationalWithdrawn

    Isoflavone is a soy phytoestrogen and a biologically active component of several agriculturally important legumes such as soy, peanut, green peas, chick peas and alfalfa . Soybean is an exceptionally rich source of dietary isoflavones, w...