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Displaying results 2131 - 2140 of 10000 in total
  1. Pathway

    Phosphatidylethanolamine Biosynthesis PE(24:1(15Z)/24:0)

    smpdb.ca/view/SMP0015894
    Metabolic

    Phosphatidylethanolamines (PE) are a class of phospholipids that incorporate a phosphoric acid headgroup into a diacylglycerol backbone. They are the second most abundant phospholipid in eukaryotic cell membranes, and contrary to phospha...

    Drugs: Choline · Serine · Phosphatidyl serine · ATP · Cytidine-5'-Triphosphate · Ethanolamine +1 more
  2. Drug

    ATX-101

    go.drugbank.com/drugs/DB05780
    Investigational

    ATX-101 demonstrates a relative selectivity for fat over other tissues. … ATX-101 (medical), sodium deoxycholate for subcutaneous injection, is being evaluated as a treatment for the reduction of localized fat deposits.

  3. Drug

    DYN-101

    go.drugbank.com/drugs/DB17921
    Investigational

    DYN-101 is an antisense product candidate designed to reduce the expression of dynamin 2 protein.

    Synonyms: DYN 101, 5’-cEtG-sp-cEt5MeU-sp-cEt5MeU-sp-dT-sp-dA-sp-dT-sp-dT-spdA-sp-dT-sp-dA-sp-dG-sp-dG-sp-dG-sp-cEt5MeC-sp-cEt5MeU-sp-cEt5MeU-3’
  4. Drug

    OTL-102

    go.drugbank.com/drugs/DB18642
    Experimental

    OTL-102 consists of autologous CD34+ enriched cells that contain hematopoietic stem and progenitor cells transduced ex vivo using a lentiviral vector encoding the human gp91phox gene. … It is being investigated for the treatment of X-linked chronic granulomatous disease.

    Synonyms: Autologous CD34+ enriched cell population that contains hematopoietic stem and progenitor cells transduced ex vivo using a lentiviral vector encoding the human gp91phox gene
  5. Drug

    MYR-101

    go.drugbank.com/drugs/DB17075
    Investigational

    It is caused by a mutation in the aspartoacylase gene (_ASPA_), which leads to a deficiency of the aspartoacylase enzyme (ASPA). … When not properly metabolized , NAA accumulates in the brain and negatively affects myelin production. MYR-101 targets oligodendrocytes and delivers functional ASPA.

  6. Drug

    AVB-101

    go.drugbank.com/drugs/DB18416
    Investigational

    AVB-101 is a recombinant AAV9 vector encoding the human progranulin (PGRN) gene.

  7. Drug

    RBIO-101

    go.drugbank.com/drugs/DB18425
    Experimental

    RBIO-101 is a recombinant adeno-associated virus vector encoding human CYP4V2 protein.

  8. Drug

    Diamorphine

    go.drugbank.com/drugs/DB01452
    ApprovedIllicit

    It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. … (Merck Index, 11th ed) Internationally, diamorphine is controlled under Schedules I and IV of the Single Convention on Narcotic Drugs.

    Synonyms: (5α,6α)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol diacetate (ester)Categories: Heterocyclic Compounds with 4 or More Rings, Drugs Used in Opioid Dependence
  9. Drug

    Nitrogen

    go.drugbank.com/drugs/DB09152
    ApprovedInvestigationalVet approved

    Nitrogen is a chemical element with symbol N and atomic number 7. At room temperature, it is a transparent, odorless diatomic gas. … Liquid nitrogen helps in removal of skin lesions through necrosis, which results from the freezing and thawing of cells. Cryotherapy usually done in doctors' office.

    Mixtures: Co-NE-O2-N2 Mixture, Lung Diffusion Test Mix No Ne CoProducts: Nitrogen 100%, N/A
  10. Drug

    EDIT-101

    go.drugbank.com/drugs/DB18687
    Investigational

    EDIT-101 is a recombinant adeno-associated virus pseudotyped with serotype 5 viral capsid encoding CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats associated protein 9) gene editing

    Synonyms: a recombinant adeno-associated virus pseudotyped with serotype 5 viral capsid encoding CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats associated protein 9) gene editing constructs