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Quinine
go.drugbank.com/drugs/DB00468ApprovedInvestigationalAn alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyret...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesFluoxetine
go.drugbank.com/drugs/DB00472ApprovedInvestigationalVet approvedFluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly pre...
Synonyms: (+-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-P-tolyl)oxy)propylamineCategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesDuloxetine
go.drugbank.com/drugs/DB00476ApprovedInvestigationalDuloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymb...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesCelecoxib
go.drugbank.com/drugs/DB00482ApprovedInvestigationalCelecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptom...
Synonyms: p-(5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamideCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesCimetidine
go.drugbank.com/drugs/DB00501ApprovedInvestigationalIt also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Categories: P-glycoprotein inducers, P-glycoprotein substratesCarteolol
go.drugbank.com/drugs/DB00521ApprovedA beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesLercanidipine
go.drugbank.com/drugs/DB00528ApprovedInvestigationalWithdrawnLercanidipine is a calcium channel blocker of the dihydropyridine class. It is sold under various commercial names including Zanidip.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsPyridostigmine
go.drugbank.com/drugs/DB00545ApprovedInvestigationalMyasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, a...
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersAdinazolam
go.drugbank.com/drugs/DB00546ExperimentalAdinazolam (Deracyn®) is a benzodiazepine derivative with anxiolytic, anticonvulsant, sedative, and antidepressant properties. Adinazolam was first developed to enhance the antidepressant effects of alprazolam. It has never been approved...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesZafirlukast
go.drugbank.com/drugs/DB00549ApprovedZafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inhibitors