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Sulfadoxine
go.drugbank.com/drugs/DB01299ApprovedInvestigationalWithdrawnA long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.
Cefradine
go.drugbank.com/drugs/DB01333ApprovedWithdrawnA semi-synthetic cephalosporin antibiotic.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersMestranol
go.drugbank.com/drugs/DB01357ApprovedWithdrawnThe 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesPenbutolol
go.drugbank.com/drugs/DB01359ApprovedInvestigationalWithdrawnPenbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergi...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesParamethasone
go.drugbank.com/drugs/DB01384ExperimentalA glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-reta...
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 SubstratesDanazol
go.drugbank.com/drugs/DB01406ApprovedInvestigationalA synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used i...
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 Inhibitors5-Methoxy-N,N-diisopropyltryptamine
go.drugbank.com/drugs/DB01441ExperimentalIllicit5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a tryptamine derivative and shares many similarities with schedule I tryptamine hallucinogens such as alpha-ethyltryptamine, N,N-dimethyltryptamine, N,N-diethyltryptamine, bufotenine, p...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesBarbital
go.drugbank.com/drugs/DB01483ExperimentalIllicitA long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice for central nervous system depression. Barbita...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersAndrostenedione
go.drugbank.com/drugs/DB01536IllicitInvestigationalA delta-4 C19 steroid that is produced not only in the testis, but also in the ovary and the adrenal cortex. Depending on the tissue type, androstenedione can serve as a precursor to testosterone as well as estrone and estradiol.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesFlunitrazepam
go.drugbank.com/drugs/DB01544ApprovedIllicitFlunitrazepam is a benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior....
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Substrates