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Complement C5
go.drugbank.com/bio_entities/BE0000855TargetHumansPrecursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that … Activated downstream of classical, alternative, lectin and GZMK complement pathways (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:39914456, PubMed:39814882, PubMed:6554279)
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4Imetelstat
go.drugbank.com/drugs/DB14909ApprovedInvestigational[erythropoietin]), but primary resistance to these agents is frequent - the median response duration is 18 to 24 months, with most responders (70%) relapsing due to loss of sensitivity of erythroid progenitors … cell morphology and a risk for transformation to acute myeloid leukemia.
Categories: Antineoplastic and Immunomodulating Agents, Nucleic Acids, Nucleotides, and NucleosidesAndusomeran
go.drugbank.com/drugs/DB18227ApprovedInvestigational[L40074,L48832,L48837] It is similar to previous mRNA vaccines developed by Moderna (e.g. [elasomeran], [imelasomeran]), but is designed to be effective against the Omicron XBB.1.5 subvariant.
Praziquantel
go.drugbank.com/drugs/DB01058ApprovedInvestigationalVet approved[A263201] The efficacy of praziquantel in treating parasitic flatworms infection with low cost (~US$0.20 drug cost to treat a child) makes it an integral to WHO's plan to eliminate schistosomiasis by 2030 … Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis.
Categories: Quinoline Derivatives and Related Substances, Antiparasitic Products, Insecticides and RepellentsRiltozinameran
go.drugbank.com/drugs/DB17095ApprovedInvestigational[L43922] It tends to cause less severe disease but is significantly more virulent than both the original virus and earlier variants (e.g. Delta). … It is administered in combination with [tozinameran] for active immunization against COVID-19 caused by SARS-CoV-2, including infection caused by Omicron BA.1[L45419]
Arbutamine
go.drugbank.com/drugs/DB01102ApprovedArbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in
Categories: Adrenergic and Dopaminergic AgentsBexagliflozin
go.drugbank.com/drugs/DB12236ApprovedInvestigationalBexagliflozin is a highly specific and potent sodium-glucose co-transporter 2 (SGLT2) inhibitor. … [A256408] By inhibiting SGLT2, bexagliflozin reduces renal reabsorption of filtered glucose and increases urinary glucose excretion, which reduces blood glucose levels independently of insulin sensitivity
Categories: Alimentary Tract and MetabolismHomatropine methylbromide
go.drugbank.com/drugs/DB00725ApprovedIt may also be used to prevent nausea, vomiting, and motion sickness. … Homatropine methylbromide is a quaternary ammonium muscarinic acetylcholine receptor antagonist belonging to the group of medicines called anti-muscarinics.
Mixtures: BONESPAS GOTAS COMPOSITE NF, Hydrocodone Bitartrate and Homatropine MethylbromideCategories: Alimentary Tract and Metabolism, Belladonna and Derivatives, PlainNasal Polyps
go.drugbank.com/conditions/DBCOND0004147Drugs: BudesonideSynonyms: Multiple polyps of nasal cavity and/or nasal sinus, Multiple polyps of nasal cavity and/or nasal sinus (disorder)Thrombin
go.drugbank.com/drugs/DB11300ApprovedInvestigationalPatients who are know or suspected to have antibodies to bovine thrombin and/or bovine factor V should not be re-exposed to the product [FDA Label]. … These antibodies may subsequently cross-react with endogenous human factor V and lead to its deficiency [FDA Label].
Mixtures: Tisseel Lyo - Pulver und Lösungsmittel für einen GewebekleberCategories: Enzymes and Coenzymes, Blood and Blood Forming Organs