Search
Tafenoquine
go.drugbank.com/drugs/DB06608ApprovedInvestigationalTafenoquine is an 8-aminoquinoline analogue of primaquine which varies only on the presence of a 5-phenoxy group. … [A35690] Tafenoquine was further developed collaboratively between GlaxoSmithKline and Medicines for Malaria Venture.[A35677] It was FDA approved on July 20, 2018.[L3770]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesMitotane
go.drugbank.com/drugs/DB00648ApprovedInvestigationalIt has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma[A263010] and is used off-label for the management of Cushing's syndrome.[A263016] … Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and
Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A InducersSynonyms: o,p'-DDDRecombinant stabilized RSV A prefusion F antigen
go.drugbank.com/drugs/DB18713ApprovedInvestigational[L48066] Abrysvo was first approved by the FDA in May 2023 for use in patients ≥60 years of age, and received subsequent approval in August 2023 for use in pregnant individuals for the protection of … [L49560] It is the first RSV vaccine approved for use in pregnant patients to prevent RSV in infants.[L49555]
Aminoglutethimide
go.drugbank.com/drugs/DB00357ApprovedWithdrawnIt was formerly used for its weak anticonvulsant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p454) … An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens.
Synonyms: p-Aminoglutethimide, 2-(p-Aminophenyl)-2-ethylglutarimideCategories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP2C19 InducersVarenicline
go.drugbank.com/drugs/DB01273ApprovedInvestigationalFood and Drug Administration warned that Varenicline, in the form of Pfizer Inc's quit-smoking drug, Chantix, has been associated with seizures and that some patients who drink while taking the drug may … Pfizer is conducting an additional safety study of the drug, results of which are expected in late 2015.
Categories: Cholinergic Receptor AgonistMephentermine
go.drugbank.com/drugs/DB01365ApprovedWithdrawnAlthough the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. … It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia.
Categories: Adrenergic alpha-1 Receptor AgonistsPirlindole
go.drugbank.com/drugs/DB09244ExperimentalPirlindole is a selective, reversible inhibitor of monoamine oxidase (MAO) subtype A (MAO-A) that is approved in several European and non-European countries for the treatment of major depression. … The antidepressant efficacy and safety of pirlindole have been demonstrated in numerous studies and, supported by many years of clinical experience in the treatment of depression.
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Serotonin Receptor AntagonistsCorticorelin ovine triflutate
go.drugbank.com/drugs/DB09067ApprovedIt provides a differential diagnosis for Cushing's disease (a pituitary source of ACTH excess) or of ectopic ACTH syndrome (an ectopic source of ACTH excess). … Endogenous forms hCRH are involved in the stress response and its main function is stimulation of the pituitary to release ACTH.
Categories: Tests for Pituitary FunctionVismodegib
go.drugbank.com/drugs/DB08828ApprovedInvestigationalAfterwards, it is silenced in all cells and tissues, except for hair, skin and stem cells. … [A258608,L45803] In January 2012, vismodegib was approved by the FDA for the treatment of adult basal cell carcinoma.
Categories: Smoothened Receptor Antagonists, P-glycoprotein substratesLarotrectinib
go.drugbank.com/drugs/DB14723ApprovedInvestigationalLarotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays … an important role in tumor cell growth and survival.
Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates