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Peppermint oil
go.drugbank.com/drugs/DB11198ApprovedInvestigationalExtracted from the stem, leaves, and flowers of Mentha piperita L. plant, peppermint oil (Mentha piperita) is a popular essential oil used in aromatherapy for both external and internal use. Mentha piperita is a hybrid of spearmint (Ment...
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP3A InhibitorsPoloxamer 407
go.drugbank.com/drugs/DB11252InvestigationalPoloxamer 407 is a polyoxyethylene polymer and hydrophilic non-ionic surfactant. It consists of a central hydrophobic block of polypropylene glycol that is flanked on each side by polyethylene glycol blocks, both hydrophilic in nature. P...
Categories: P-glycoprotein inhibitorsDihydro-alpha-ergocryptine
go.drugbank.com/drugs/DB11274ApprovedAlpha-dihydroergocryptine is usually referred to the mixture of the alpha and beta dihydroergocryptine. These two compounds are differentiated in the position of a methyl group. This structural difference is due to a proteinogenic amino ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProthrombin
go.drugbank.com/drugs/DB11311ApprovedInvestigationalProthrombin Complex Concentrate (Human), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with acute major bleeding.
Mixtures: Beriplex P/n 500, Beriplex P/n 1000Nonivamide
go.drugbank.com/drugs/DB11324ApprovedThe structures of [DB06774] and nonivamide differ only slightly with respect to the fatty acid moiety of the side chain (8-methyl nonenoic acid versus nonanoic acid) [F31].
Poloxamer 188
go.drugbank.com/drugs/DB11333ApprovedPoloxamer 188 (P188) is a nonionic block linear copolymer that exhibits rheologic, anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models . Composed of two hydrophilic side-chains attached to a ...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A InhibitorsAlectinib
go.drugbank.com/drugs/DB11363ApprovedInvestigationalAlectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesChloroform
go.drugbank.com/drugs/DB11387ApprovedVet approvedWithdrawnChloroform is an organic small molecule, member of the family of the chloromethanes that presents a formula of CHCl3. It is a colorless, sweet-smelling, dense liquid that is produced on a large scale as a precursor to PTFE and refrigeran...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 SubstratesEnrofloxacin
go.drugbank.com/drugs/DB11404InvestigationalVet approvedEnrofloxacin is an antibiotic agent from the fluoroquinolone family produced by the Bayer Corporation. Enrofloxacin is approved by the FDA for its veterinary use. Due to the identification of fluoroquinolone-resistant strains of Campylob...
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP1A2 InhibitorsFenbendazole
go.drugbank.com/drugs/DB11410InvestigationalVet approvedFenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms, pinworms, ae...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 Substrates