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Erythropoietin
go.drugbank.com/drugs/DB00016ApprovedInvestigationalErythropoietin (EPO) is a growth factor produced in the kidneys that stimulates the production of red blood cells. … The biosimilar is approved by the FDA and EMA as a safe, effective and affordable biological product and displays equivalent clinical efficacy, potency, and purity to the reference product [A7504].
Synonyms: SH-polypeptide-72, 1-165-Erythropoietin (human clone λHEPOFL13 protein moiety), glycoform αProducts: EPORATIO 5000 I E/0.5ML SD, BIOPOIN 1000 I E /0.5ML SDLopinavir
go.drugbank.com/drugs/DB01601ApprovedInvestigationalcannot be cleaved, thus preventing the activity of the HIV-1 protease. … [saquinavir], [nelfinavir]), lopinavir is a peptidomimetic molecule - it contains a hydroxyethylene scaffold that mimics the peptide linkage typically targeted by the HIV-1 protease enzyme but which itself
Mixtures: LOPINAVIR E RITONAVIR MYLAN, LOPINAVIR E RITONAVIR MYLANCategories: Antivirals used in combination for the treatment of HIV infections, P-glycoprotein inducersHuman varicella-zoster immune globulin
go.drugbank.com/drugs/DB11621ApprovedInvestigationalThe therapeutic efficacy is proven if administered within 4 days of exposure to varicella zoster virus. … lack evidence of immunity to varicella and for whom varicella vaccine is contraindicated.
Synonyms: Human herpesvirus 3 immune globulinRosuvastatin
go.drugbank.com/drugs/DB01098ApprovedInvestigationalfound in clinical studies to result in a 45.8% to 54.6% decreases in LDL cholesterol levels, which is about three-fold more potent than [atorvastatin]'s effects on LDL cholesterol. … Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage
Synonyms: (3R,5S,6E)-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(ethyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid, (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acidMixtures: ROSUVINA LEGRAND® E 10/40, ROSUVINA LEGRAND® E 10/20Patisiran
go.drugbank.com/drugs/DB14582ApprovedIt is marketed as Onpattro which is formulated as patisiran within a liposome envelope for better delivery to the liver, where transthyretin is produced. … Patisiran is a first in class short interfering RNA for the treatment of patients with polyneuropathy caused by hereditary transthyretin-mediated amyloidosis [L4220].
Categories: Compounds used in a research, industrial, or household settingAnisindione
go.drugbank.com/drugs/DB01125ApprovedII, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver. … Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors
Synonyms: 2-p-Anisyl-1,3-indandione, 2-(4-Methoxyphenyl)indan-1,3-dioneEvolocumab
go.drugbank.com/drugs/DB09303ApprovedInvestigationalEvolocumab is designed to bind to PCSK9 and inhibit PCSK9 from binding to LDL receptors on the liver surface, resulting in more LDL receptors on the surface of the liver to remove LDL-C from the blood. … PCSK9 is a protein that targets LDL receptors for degradation, therefore reducing the liver's ability to remove LDL-cholesterol (LDL-C), or "bad" cholesterol, from the blood.
Products: REPATHA 140 MG/ML SC ENJEKSIYONLUK COZELTI ICEREN KULLANIMA HAZIR ENJEKTOR, 1 ADET, REPATHA 140 MG/ML SC ENJEKSIYONLUK COZELTI ICEREN KULLANIMA HAZIR KALEM, 1 ADETCapmatinib
go.drugbank.com/drugs/DB11791ApprovedInvestigational[A199122] This co-occurrence has made c-Met a desirable target in the treatment of NSCLC. … [L13347] The presence of the mutation must be confirmed by an FDA-approved test, such as the FoundationOne CDx assay (manufactured by Foundation Medicine, Inc.), which was approved by the FDA on the same
Categories: MATE 2-K Inhibitors, MATE 1 InhibitorsPyrimethamine
go.drugbank.com/drugs/DB00205ApprovedInvestigationalVet approvedOne of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
Synonyms: 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine, 2,4-Diamino-5-(P-chlorophenyl)-6-ethylpyrimidineCategories: MATE 1 Inhibitors, MATE 2 InhibitorsBenzydamine
go.drugbank.com/drugs/DB09084ApprovedInvestigationalMoreover, unlike aspirin-like NSAIDs which are acids or metabolised to acids, benzydamine is in fact a weak base. … Benzydamine (also known as Tantum Verde or Difflam), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties
Mixtures: TANTUM VERDE GENGIVITE E STOMATITE, TANTUM VERDE GENGIVITE E STOMATITECategories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 1-Ring