Human varicella-zoster immune globulin is a solution of antibodies used for post exposure prophylaxis of varicella infections in high risk populations, as well as to reduce the severity of infections. Human varicella-zoster immune globulin is a solvent/detergent-treated sterile liquid preparation of purified human immune globulin G (IgG) containing antibodies to varicella zoster virus (anti-VZV).
- Mechanism
- Curator reviewed · 1 reference
Immunoglobulins are derived from human plasma and synthesized from plasma cells that recognize a broad spectrum of specific antigenic determinants. Derived from a pool of healthy human plasma, Human Varicella-Zoster Immune Globulin is a solvent/detergent-treated sterile lyophilized preparation of purified human immune globulin G (IgG) containing antibodies to varicella zoster virus. The anti-VZV antibodies in VariZIG™ are thought to bind to proteins on the varicella virus; thereby, preventing or reducing the severity and progression of varicella infections.
- Primary indication
- Indicated for preventing and reducing the severity of chicken pox (varicella zoster virus) infections in high risk individuals within 4 days of exposure to varicella zoster virus.Curator reviewed · 1 structured indication
- First approval
- Canada, 1997 · United States, 2013
- Also known as
- Human herpesvirus 3 immune globulin · Varicella zoster immune globulin · Varicella zoster immune globulin (human) · Varicella zoster immune globulin human · Varicella zoster immunoglobulin (human)
- Brand names
Resolves to
What you can answer from here — as of May 03, 2025
Which other approved drugs treat the same conditions as Human varicella-zoster immune globulin, and which companies have late-stage candidates in those indications?
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