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Displaying results 2241 - 2250 of 10000 in total
  1. Drug

    Interferon alfa-2b

    go.drugbank.com/drugs/DB00105
    ApprovedInvestigational

    Interferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. … It is used extensively as an antiviral or antineoplastic agent.

    Synonyms: Interferon alfa 2-b, Interferon α-2bMixtures: Rebetron Ready To Use Solution (albumin(human)free) (6000000 Iu/ml and 200mg Capsules), Rebetron Solution (albumin (human) Free) (18 Miu Multi-dose Pen / 200mg Capsules)
  2. Drug

    Vericiguat

    go.drugbank.com/drugs/DB15456
    ApprovedInvestigational

    [A227458,A227488] Cyclic GMP acts as a second messenger, activating a number of downstream signaling cascades that elicit a broad variety of effects, and these diverse cellular effects have implicated … [A227458] As a direct stimulator of sGC, vericiguat mitigates the need for a functional NO-sGC-cGMP axis and thereby helps to prevent the myocardial and vascular dysfunction associated with decreased sGC

    Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substratesProducts: VERQUVO 10 MG FİLM KAPLI TABLET , 28 ADET, VERQUVO 5 MG FİLM KAPLI TABLET , 28 ADET
  3. Drug

    Cyclosporine

    go.drugbank.com/drugs/DB00091
    ApprovedInvestigationalVet approved

    It is isolated from the fungus _Beauveria nivea_. … Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions.

    Synonyms: Cyclosporin A, Cyclosporine ACategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
  4. Drug

    UM-171

    go.drugbank.com/drugs/DB19449
    Investigational

    UM-171 is a pyrimidoindole derivative that is an agonist of ex vivo hematopoietic stem cell expansion and thus supports the expansion of hematopoietic stem cells.[A264868, A264873]

    Synonyms: ((1r, 4r)-n1-(2-benzyl-7-(2-methyl-2h-tetrazol-5-yl)-9h-pyrimido(4,5-b)indol-4-yl)cyclohexane-1,4-diamine, 1,4-cyclohexanediamine, n1-(7-(2-methyl-2h-tetrazol-5-yl)-2-(phenylmethyl)-9h-pyrimido(4,5-b)indol-4-yl)-, trans-
  5. Drug

    Amphotericin B

    go.drugbank.com/drugs/DB00681
    ApprovedInvestigational

    ranging from 0.03 to 1.0 mcg/mL in vitro. … Amphotericin B shows a high order of in vitro activity against many species of fungi.

    Synonyms: AMPH-b, Amfotericina BSalts: Amphotericin B Cholesteryl Sulfate Complex
  6. Drug

    6-[18F]-Fluoro-L-m-tyrosine

    go.drugbank.com/drugs/DB17621
    Experimental

    Synonyms: 2-fluoro-5-hydroxy-l-phenylalanine F-18, L-phenylalanine, 2-fluoro-5-hydroxy-F-18
  7. Drug

    Levamisole

    go.drugbank.com/drugs/DB00848
    ApprovedInvestigationalVet approvedWithdrawn

    [A178123] Interestingly, levamisole has been found as an adulterant in cocaine and can lead to a variety of adverse effects in individuals using this drug.[A178120] … [A178117] It was manufactured by _Janssen_ and first used in 1969 as an agent to treat worm infestations[A178123] Levamisole was approved by the FDA in 1990 as an adjuvant treatment for colon cancer.

    Categories: Heterocyclic Compounds, 1-RingProducts: PARAKS 40 MG/5 ML ŞURUP, 30 ML, SITRAKS 40 MG/5 ML SURUP, 30 ML
  8. Drug

    Nandrolone decanoate

    go.drugbank.com/drugs/DB08804
    ApprovedIllicitInvestigational

    [A233849] Nandrolone decanoate was granted FDA approval on 5 October 1962.[L32564] … [A233789,A233849,L32564,L9464] The process for creating esters of [nandrolone] was patented in Spain in 1959[L33244] and in 1960, it was described as having a long duration of action and strong anabolic

    Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesSynonyms: 19-nortestosterone decanoate
  9. Drug

    Quabodepistat

    go.drugbank.com/drugs/DB17770
    Investigational

    Synonyms: 2(1H)-QUINOLINONE, 5-(((3R,4R)-1-(4-CHLORO-2,6-DIFLUOROPHENYL)-3,4-DIHYDROXY-4-PIPERIDINYL)METHOXY)-8-FLUORO-3,4-DIHYDRO-, 5-(((3r,4r)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidin-4-yl)methoxy)-8-fluoro-3,4-dihydroquinolin-2(1h)-one
  10. Drug

    Narmafotinib

    go.drugbank.com/drugs/DB18463
    Investigational

    Synonyms: 2-(2-(2-((2-methoxy-4-(1-methyl-4-piperidinyl)phenyl)amino)-5-(trifluoromethyl)-4-pyrimidinyl)ethyl)benzeneacetamide, Benzeneacetamide, 2-(2-(2-((2-methoxy-4-(1-methyl-4-piperidinyl)phenyl)amino)-5-(trifluoromethyl)-4-pyrimidinyl)ethyl)-