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Clopidogrel
go.drugbank.com/drugs/DB00758ApprovedInvestigational[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and … in recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and
DTS-201
go.drugbank.com/drugs/DB06071ExperimentalDTS-201 is a prodrug of doxorubicin, a widely used anti-cancer drug that Diatos intends to develop for the treatment of various solid tumors. It is activated in the tumor environment. … DTS-201 may be suitable for the treatment of many types of solid tumors, including tumors sensitive to doxorubicin and potentially other tumors which are not currently treated with doxorubicin but which
Ezogabine
go.drugbank.com/drugs/DB04953ApprovedWithdrawnIt is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures
Conjugated estrogens
go.drugbank.com/drugs/DB00286ApprovedInvestigational[T475] The conjugated estrogen mixture was approved for marketing in US in 1942 based on the efficacy against certain conditions. … However, until 1986 official clinical trials were performed and this product was determined to be effective for the treatment of osteoporosis.
Dicoumarol
go.drugbank.com/drugs/DB00266ApprovedDicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
Tirapazamine
go.drugbank.com/drugs/DB04858InvestigationalFor all these reasons, the combination of tirapazamine with other anticancer treatments is highly recommended. … Tirapazamine entered phase III testing in 2006 for patients with head and neck cancer and gynecological cancer, as well as for other solid tumor cancer types.
Pyrazinamide
go.drugbank.com/drugs/DB00339ApprovedInvestigationalA pyrazine that is used therapeutically as an antitubercular agent.
Categories: Antiinfectives for Systemic Use, Drugs for Treatment of TuberculosisAminosalicylic acid
go.drugbank.com/drugs/DB00233ApprovedInvestigationalAn antitubercular agent often administered in association with isoniazid. The sodium salt of the drug is better tolerated than the free acid.
Categories: Antiinfectives for Systemic Use, Drugs for Treatment of TuberculosisHyoscyamine
go.drugbank.com/drugs/DB00424ApprovedInvestigational[A228713] Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimuscarinic properties. … [A228423] It is commonly extracted from plants in the _Solanaceae_ or nightshade family.[A228423] Research into the action of hyoscyamine in published literature dates back to 1826.
Categories: Drugs for Functional Gastrointestinal DisordersTrypsin
go.drugbank.com/drugs/DB11237ApprovedInvestigationalVet approvedWhen converted from its zymogen trypsinogen, trypsin is available as an active peptide hydrolase (EC 3.4.21.4) form to cleave peptide chains, mainly at the carboxyl side of the amino acids lysine or arginine … Trypsin contains a nucleophilic residue Ser in the enzyme active site which attacks the carbonyl moiety of the substrate peptide bond to form an acyl-enzyme intermediate [A27241].
Categories: Preparations for Treatment of Wounds and Ulcers